CGA (glycoprotein hormones, alpha polypeptide)

2007-02-01  

Identity

HGNC
LOCATION
6q14.3
LOCUSID
ALIAS
CG-ALPHA,FSHA,GPA1,GPHA1,GPHa,HCG,LHA,TSHA
FUSION GENES

Other Information

Locus ID:

NCBI: 1081
MIM: 118850
HGNC: 1885
Ensembl: ENSG00000135346

Variants:

dbSNP: 1081
ClinVar: 1081
TCGA: ENSG00000135346
COSMIC: CGA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135346ENST00000369582A0A0R4J2F0
ENSG00000135346ENST00000610310A0A087WYZ4
ENSG00000135346ENST00000625577A0A0D9SFJ6
ENSG00000135346ENST00000627148P01215
ENSG00000135346ENST00000627148Q6I9S8
ENSG00000135346ENST00000630630A0A0D9SGA7

Expression (GTEx)

0
500
1000
1500
2000
2500
3000
3500

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
GnRH signaling pathwayKEGGko04912
Autoimmune thyroid diseaseKEGGko05320
Neuroactive ligand-receptor interactionKEGGhsa04080
GnRH signaling pathwayKEGGhsa04912
Autoimmune thyroid diseaseKEGGhsa05320
Ovarian steroidogenesisKEGGhsa04913
Ovarian steroidogenesisKEGGko04913
Prolactin signaling pathwayKEGGhsa04917
Prolactin signaling pathwayKEGGko04917
Thyroid hormone synthesisKEGGhsa04918
Thyroid hormone synthesisKEGGko04918
Regulation of lipolysis in adipocytesKEGGhsa04923
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
N-glycan antennae elongation in the medial/trans-GolgiREACTOMER-HSA-975576
Reactions specific to the complex N-glycan synthesis pathwayREACTOMER-HSA-975578
Peptide hormone metabolismREACTOMER-HSA-2980736
Peptide hormone biosynthesisREACTOMER-HSA-209952
Glycoprotein hormonesREACTOMER-HSA-209822
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Hormone ligand-binding receptorsREACTOMER-HSA-375281
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Metabolism of steroid hormonesREACTOMER-HSA-196071
Mineralocorticoid biosynthesisREACTOMER-HSA-193993
Androgen biosynthesisREACTOMER-HSA-193048
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Amine-derived hormonesREACTOMER-HSA-209776
Thyroxine biosynthesisREACTOMER-HSA-209968
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factorsREACTOMER-HSA-8864260
TFAP2 (AP-2) family regulates transcription of growth factors and their receptorsREACTOMER-HSA-8866910

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
343411002022Prevalence and predictors of colonoscopic findings in patients with autoimmune gastritis.0
343411002022Prevalence and predictors of colonoscopic findings in patients with autoimmune gastritis.0
343520462021Myocardial perfusion SPECT as a potential mediator on circulating chromogranin A in patients with old myocardial infarction.0
343520462021Myocardial perfusion SPECT as a potential mediator on circulating chromogranin A in patients with old myocardial infarction.0
323778672020Analysis of the human chorionic gonadotropin protein at the intact level by HILIC-MS and comparison with RPLC-MS.5
327699972020GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer.47
323778672020Analysis of the human chorionic gonadotropin protein at the intact level by HILIC-MS and comparison with RPLC-MS.5
327699972020GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer.47
302873992019Hyperglycosylated hCG activates LH/hCG-receptor with lower activity than hCG.8
305976622019Activation of NF-κB signaling pathway during HCG-induced VEGF expression in luteal cells.9
308512982019Growth differentiation factor 9 promotes follicle-stimulating hormone-induced progesterone production in chicken follicular granulosa cells.22
309151282019Melatonin receptor depletion suppressed hCG-induced testosterone expression in mouse Leydig cells.16
309407202019Thyrotropin aggravates atherosclerosis by promoting macrophage inflammation in plaques.6
313620002019Human chorionic gonadotropin and IL-35 contribute to the maintenance of peripheral immune tolerance during pregnancy through mediating the generation of IL-10(+) or IL-35(+) Breg cells.8
302873992019Hyperglycosylated hCG activates LH/hCG-receptor with lower activity than hCG.8

Citation

Dessen P

CGA (glycoprotein hormones, alpha polypeptide)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46217/js/js/lib/favicon/favicon-16x16.png