CGA (glycoprotein hormones, alpha polypeptide)

2007-02-01 Affiliation

Identity

HGNC

CGA

LOCATION

6q14.3

LOCUSID

1081

ALIAS

CG-ALPHA,FSHA,GPA1,GPHA1,GPHa,HCG,LHA,TSHA

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1081
MIM: 118850
HGNC: 1885
Ensembl: ENSG00000135346

Variants:

dbSNP: 1081
ClinVar: 1081
TCGA: ENSG00000135346
COSMIC: CGA

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000135346	ENST00000369582	A0A0R4J2F0
ENSG00000135346	ENST00000610310	A0A087WYZ4
ENSG00000135346	ENST00000625577	A0A0D9SFJ6
ENSG00000135346	ENST00000627148	P01215
ENSG00000135346	ENST00000627148	Q6I9S8
ENSG00000135346	ENST00000630630	A0A0D9SGA7

Expression (GTEx)

500

1000

1500

2000

2500

3000

3500

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
GnRH signaling pathway	KEGG	ko04912
Autoimmune thyroid disease	KEGG	ko05320
Neuroactive ligand-receptor interaction	KEGG	hsa04080
GnRH signaling pathway	KEGG	hsa04912
Autoimmune thyroid disease	KEGG	hsa05320
Ovarian steroidogenesis	KEGG	hsa04913
Ovarian steroidogenesis	KEGG	ko04913
Prolactin signaling pathway	KEGG	hsa04917
Prolactin signaling pathway	KEGG	ko04917
Thyroid hormone synthesis	KEGG	hsa04918
Thyroid hormone synthesis	KEGG	ko04918
Regulation of lipolysis in adipocytes	KEGG	hsa04923
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Asparagine N-linked glycosylation	REACTOME	R-HSA-446203
Transport to the Golgi and subsequent modification	REACTOME	R-HSA-948021
N-glycan antennae elongation in the medial/trans-Golgi	REACTOME	R-HSA-975576
Reactions specific to the complex N-glycan synthesis pathway	REACTOME	R-HSA-975578
Peptide hormone metabolism	REACTOME	R-HSA-2980736
Peptide hormone biosynthesis	REACTOME	R-HSA-209952
Glycoprotein hormones	REACTOME	R-HSA-209822
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Hormone ligand-binding receptors	REACTOME	R-HSA-375281
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (s) signalling events	REACTOME	R-HSA-418555
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Metabolism of steroid hormones	REACTOME	R-HSA-196071
Mineralocorticoid biosynthesis	REACTOME	R-HSA-193993
Androgen biosynthesis	REACTOME	R-HSA-193048
Metabolism of amino acids and derivatives	REACTOME	R-HSA-71291
Amine-derived hormones	REACTOME	R-HSA-209776
Thyroxine biosynthesis	REACTOME	R-HSA-209968
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	REACTOME	R-HSA-8864260
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	REACTOME	R-HSA-8866910

Protein levels (Protein atlas)

Not detected

Low

Medium

High

cerebral cortex

cerebellum

hippocampus

caudate

thyroid gland

parathyroid gland

adrenal gland

pituitary gland

nasopharynx

bronchus

lung

oral mucosa

salivary gland

esophagus

stomach 1

stomach 2

duodenum

small intestine

colon

rectum

liver

gallbladder

pancreas

kidney

urinary bladder

testis

epididymis

seminal vesicle

prostate

vagina

ovary

fallopian tube

endometrium 1

endometrium 2

cervix, uterine

placenta

breast

heart muscle

smooth muscle

skeletal muscle

soft tissue 1

soft tissue 2

adipose tissue

skin 1

skin 2

appendix

spleen

lymph node

tonsil

bone marrow

References

Pubmed ID	Year	Title	Citations
34341100	2022	Prevalence and predictors of colonoscopic findings in patients with autoimmune gastritis.	0
34341100	2022	Prevalence and predictors of colonoscopic findings in patients with autoimmune gastritis.	0
34352046	2021	Myocardial perfusion SPECT as a potential mediator on circulating chromogranin A in patients with old myocardial infarction.	0
34352046	2021	Myocardial perfusion SPECT as a potential mediator on circulating chromogranin A in patients with old myocardial infarction.	0
32377867	2020	Analysis of the human chorionic gonadotropin protein at the intact level by HILIC-MS and comparison with RPLC-MS.	5
32769997	2020	GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer.	47
32377867	2020	Analysis of the human chorionic gonadotropin protein at the intact level by HILIC-MS and comparison with RPLC-MS.	5
32769997	2020	GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer.	47
30287399	2019	Hyperglycosylated hCG activates LH/hCG-receptor with lower activity than hCG.	8
30597662	2019	Activation of NF-κB signaling pathway during HCG-induced VEGF expression in luteal cells.	9
30851298	2019	Growth differentiation factor 9 promotes follicle-stimulating hormone-induced progesterone production in chicken follicular granulosa cells.	22
30915128	2019	Melatonin receptor depletion suppressed hCG-induced testosterone expression in mouse Leydig cells.	16
30940720	2019	Thyrotropin aggravates atherosclerosis by promoting macrophage inflammation in plaques.	6
31362000	2019	Human chorionic gonadotropin and IL-35 contribute to the maintenance of peripheral immune tolerance during pregnancy through mediating the generation of IL-10(+) or IL-35(+) Breg cells.	8
30287399	2019	Hyperglycosylated hCG activates LH/hCG-receptor with lower activity than hCG.	8

Citation

Dessen P

CGA (glycoprotein hormones, alpha polypeptide)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46217/js/lib/meetings/favicon/favicon-32x32.png