UGT1A10 (UDP glucuronosyltransferase family 1 member A10)

2007-02-01  

Identity

HGNC
LOCATION
2q37.1
LOCUSID
ALIAS
GNT1,UDPGT,UGT-1A,UGT-1J,UGT1,UGT1-01,UGT1-10,UGT1.1,UGT1.10,UGT1A,UGT1A1,UGT1J,hUG-BR1

Other Information

Locus ID:

NCBI: 54575
MIM: 606435
HGNC: 12531
Ensembl: ENSG00000242515

Variants:

dbSNP: 54575
ClinVar: 54575
TCGA: ENSG00000242515
COSMIC: UGT1A10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000242515ENST00000344644Q9HAW8
ENSG00000242515ENST00000344644Q5DT02
ENSG00000242515ENST00000373445Q9HAW8

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Pentose and glucuronate interconversionsKEGGko00040
Ascorbate and aldarate metabolismKEGGko00053
Steroid hormone biosynthesisKEGGko00140
Retinol metabolismKEGGko00830
Porphyrin and chlorophyll metabolismKEGGko00860
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Drug metabolism - cytochrome P450KEGGko00982
Drug metabolism - other enzymesKEGGko00983
Pentose and glucuronate interconversionsKEGGhsa00040
Ascorbate and aldarate metabolismKEGGhsa00053
Steroid hormone biosynthesisKEGGhsa00140
Retinol metabolismKEGGhsa00830
Porphyrin and chlorophyll metabolismKEGGhsa00860
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Drug metabolism - cytochrome P450KEGGhsa00982
Drug metabolism - other enzymesKEGGhsa00983
Metabolic pathwaysKEGGhsa01100
Glucuronate pathway (uronate pathway)KEGGM00014
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
Glucuronate pathway (uronate pathway)KEGGhsa_M00014

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164748728mycophenolic acidChemicalPathwayassociated24220207
PA165110775SN-38ChemicalPathwayassociated
PA165958521febuxostatChemicalClinicalAnnotationassociatedPD27798726
PA420UGT1A1GeneVipGeneassociated15179404, 18004212, 18491077, 18518849, 19794410, 19997083, 8467709, 11434514
PA444065EpilepsyDiseaseClinicalAnnotationassociatedPKPD15761113, 21806385, 27900402, 28763744
PA444318GoutDiseaseClinicalAnnotationassociatedPD27798726
PA445601OsteosarcomaDiseaseClinicalAnnotationassociatedPK29791011
PA445629SeizuresDiseaseClinicalAnnotationassociatedPD27900402
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD
PA448320allopurinolChemicalClinicalAnnotationassociatedPD27798726
PA450428methotrexateChemicalClinicalAnnotationassociatedPK29791011
PA450732oxcarbazepineChemicalClinicalAnnotationassociatedPD27900402
PA451257risperidoneChemicalClinicalAnnotationassociatedPD
PA451846valproic acidChemicalClinicalAnnotation, VariantAnnotationassociatedPKPD15761113, 21806385, 28763744

References

Pubmed IDYearTitleCitations
295198532018Cooperative Regulation of Intestinal UDP-Glucuronosyltransferases 1A8, -1A9, and 1A10 by CDX2 and HNF4α Is Mediated by a Novel Composite Regulatory Element.1
295198532018Cooperative Regulation of Intestinal UDP-Glucuronosyltransferases 1A8, -1A9, and 1A10 by CDX2 and HNF4α Is Mediated by a Novel Composite Regulatory Element.1
255476282015Differences in the glucuronidation of bisphenols F and S between two homologous human UGT enzymes, 1A9 and 1A10.13
262201432015Glucuronidation of estrone and 16α-hydroxyestrone by human UGT enzymes: The key roles of UGT1A10 and UGT2B7.5
255476282015Differences in the glucuronidation of bisphenols F and S between two homologous human UGT enzymes, 1A9 and 1A10.13
262201432015Glucuronidation of estrone and 16α-hydroxyestrone by human UGT enzymes: The key roles of UGT1A10 and UGT2B7.5
242398972014Epigenetic regulation of the tissue-specific expression of human UDP-glucuronosyltransferase (UGT) 1A10.11
252649622014Electrochemically driven drug metabolism via a CYP1A2-UGT1A10 bienzyme confined in a graphene nano-cage.2
242398972014Epigenetic regulation of the tissue-specific expression of human UDP-glucuronosyltransferase (UGT) 1A10.11
252649622014Electrochemically driven drug metabolism via a CYP1A2-UGT1A10 bienzyme confined in a graphene nano-cage.2
231608182013Metabolic transformation of antitumor acridinone C-1305 but not C-1311 via selective cellular expression of UGT1A10 increases cytotoxic response: implications for clinical use.7
231608182013Metabolic transformation of antitumor acridinone C-1305 but not C-1311 via selective cellular expression of UGT1A10 increases cytotoxic response: implications for clinical use.7
220316232012Identification of UDP-glucuronosyltransferases responsible for the glucuronidation of darexaban, an oral factor Xa inhibitor, in human liver and intestine.4
226590922012Role of human UDP-glucuronosyltransferases in the biotransformation of the triazoloacridinone and imidazoacridinone antitumor agents C-1305 and C-1311: highly selective substrates for UGT1A10.6
220316232012Identification of UDP-glucuronosyltransferases responsible for the glucuronidation of darexaban, an oral factor Xa inhibitor, in human liver and intestine.4

Citation

Dessen P

UGT1A10 (UDP glucuronosyltransferase family 1 member A10)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46276/js/css/card-gene.css