SIRT7 (sirtuin 7)

2007-02-01  

Identity

HGNC
LOCATION
17q25.3
LOCUSID
ALIAS
SIR2L7
FUSION GENES

Other Information

Locus ID:

NCBI: 51547
MIM: 606212
HGNC: 14935
Ensembl: ENSG00000187531

Variants:

dbSNP: 51547
ClinVar: 51547
TCGA: ENSG00000187531
COSMIC: SIRT7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000187531ENST00000328666Q9NRC8
ENSG00000187531ENST00000572902I3L480
ENSG00000187531ENST00000575360I3L2A4

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
166187982006Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription.189
227228492012SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation.166
257923302015Stem cell aging. A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging.132
230797452013Sirtuin7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors MiR-125a-5p and MiR-125b.112
242108202013SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease.79
170037812006Altered sirtuin expression is associated with node-positive breast cancer.78
225863262012Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.68
274362292016SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability.60
191744632009Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis.59
191744632009Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis.59

Citation

Dessen P

SIRT7 (sirtuin 7)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46278/sirt7-(sirtuin-7)