SLCO1B3 (solute carrier organic anion transporter family member 1B3)

2007-02-01 Affiliation

Identity

HGNC

SLCO1B3

LOCATION

12p12.2

LOCUSID

28234

ALIAS

HBLRR,LST-2,LST-3TM13,LST3,OATP-8,OATP1B3,OATP8,SLC21A8

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 28234
MIM: 605495
HGNC: 10961
Ensembl: ENSG00000111700

Variants:

dbSNP: 28234
ClinVar: 28234
TCGA: ENSG00000111700
COSMIC: SLCO1B3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000111700	ENST00000261196	Q9NPD5
ENSG00000111700	ENST00000381545	Q9NPD5
ENSG00000111700	ENST00000540853	F5H8K0
ENSG00000111700	ENST00000544370	H0YGG9

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Bile secretion	KEGG	ko04976
Bile secretion	KEGG	hsa04976
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
SLC-mediated transmembrane transport	REACTOME	R-HSA-425407
Transport of vitamins, nucleosides, and related molecules	REACTOME	R-HSA-425397
Transport of organic anions	REACTOME	R-HSA-879518
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Bile acid and bile salt metabolism	REACTOME	R-HSA-194068
Recycling of bile acids and salts	REACTOME	R-HSA-159418

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA133950441	hmg coa reductase inhibitors	Chemical	Pathway	associated
PA134308647	rosuvastatin	Chemical	Pathway	associated
PA151958383	Gastrointestinal Stromal Tumors	Disease	ClinicalAnnotation	associated		PD	28117434
PA162372840	sunitinib	Chemical	ClinicalAnnotation	associated		PD	28117434
PA164748728	mycophenolic acid	Chemical	ClinicalAnnotation	associated		PD
PA165817016	Kidney Transplantation	Disease	ClinicalAnnotation	associated	PK	PD	17906856, 19890249, 21142914, 21878834
PA166114454	transplant rejection	Disease	ClinicalAnnotation	associated		PD
PA166114457	lung transplantation	Disease	ClinicalAnnotation	associated		PD
PA166122590	simeprevir	Chemical	LabelAnnotation	associated
PA166123207	overall survival	Disease	ClinicalAnnotation	associated		PD
PA166163418	rucaparib	Chemical	LabelAnnotation	associated
PA166163438	elbasvir / grazoprevir	Chemical	LabelAnnotation	associated
PA166195784	chronic lung allograft dysfunction	Disease	ClinicalAnnotation	associated		PD
PA443622	Carcinoma, Non-Small-Cell Lung	Disease	ClinicalAnnotation	associated		PD	26641474
PA444818	Lung Neoplasms	Disease	ClinicalAnnotation	associated		PD	26267044, 26641474
PA445062	Neoplasms	Disease	ClinicalAnnotation	associated	PK	PD	18294295
PA448500	atorvastatin	Chemical	Pathway	associated
PA448803	carboplatin	Chemical	ClinicalAnnotation	associated		PD	26267044, 26641474
PA449383	docetaxel	Chemical	ClinicalAnnotation, Pathway	associated	PK	PD	18294295, 21151855
PA449688	fluvastatin	Chemical	Pathway	associated
PA450272	lovastatin	Chemical	Pathway	associated
PA450428	methotrexate	Chemical	Pathway	associated			21317831
PA450566	mycophenolate mofetil	Chemical	ClinicalAnnotation	associated	PK	PD	17906856, 19890249, 21142914, 21878834
PA450761	paclitaxel	Chemical	ClinicalAnnotation, Pathway	associated		PD	21151855, 26267044, 26641474
PA451089	pravastatin	Chemical	Pathway	associated			25502615
PA451363	simvastatin	Chemical	Pathway	associated

References

Pubmed ID	Year	Title	Citations
18519758	2008	Effect of SLCO1B3 haplotype on testosterone transport and clinical outcome in caucasian patients with androgen-independent prostatic cancer.	75
22232210	2012	Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver.	66
21606417	2011	SLCO2B1 and SLCO1B3 may determine time to progression for patients receiving androgen deprivation therapy for prostate cancer.	59
20051929	2010	HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms.	56
21626360	2011	The uptake transporter OATP8 expression decreases during multistep hepatocarcinogenesis: correlation with gadoxetic acid enhanced MR imaging.	53
18321482	2008	Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3.	50
19419973	2009	Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia.	50
19419973	2009	Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia.	50
21266523	2011	Expression of SLCO transport genes in castration-resistant prostate cancer and impact of genetic variation in SLCO1B3 and SLCO2B1 on prostate cancer outcomes.	50
17496208	2007	Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil.	49

Citation

Dessen P

SLCO1B3 (solute carrier organic anion transporter family member 1B3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46289/slco1b3