ACTR3 (actin related protein 3)

2007-02-01  

Identity

HGNC
LOCATION
2q14.1
LOCUSID
ALIAS
ARP3
FUSION GENES

Other Information

Locus ID:

NCBI: 10096
MIM: 604222
HGNC: 170
Ensembl: ENSG00000115091

Variants:

dbSNP: 10096
ClinVar: 10096
TCGA: ENSG00000115091
COSMIC: ACTR3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115091ENST00000263238P61158
ENSG00000115091ENST00000263238A0A024RAI1
ENSG00000115091ENST00000415792F8WEW2
ENSG00000115091ENST00000443297F8WDR7
ENSG00000115091ENST00000446821F8WE84
ENSG00000115091ENST00000535589B4DXW1

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Tight junctionKEGGhsa04530
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate WASPs and WAVEsREACTOMER-HSA-5663213
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPHB-mediated forward signalingREACTOMER-HSA-3928662
Clathrin-mediated endocytosisREACTOMER-HSA-8856828

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
371625072023ARPC5 isoforms and their regulation by calcium-calmodulin-N-WASP drive distinct Arp2/3-dependent actin remodeling events in CD4 T cells.6
375492942023Transition State of Arp2/3 Complex Activation by Actin-Bound Dimeric Nucleation-Promoting Factor.4
371625072023ARPC5 isoforms and their regulation by calcium-calmodulin-N-WASP drive distinct Arp2/3-dependent actin remodeling events in CD4 T cells.6
375492942023Transition State of Arp2/3 Complex Activation by Actin-Bound Dimeric Nucleation-Promoting Factor.4
316985182020Partial loss of actin nucleator actin-related protein 2/3 activity triggers blebbing in primary T lymphocytes.14
321699002020Proline-rich 11 (PRR11) drives F-actin assembly by recruiting the actin-related protein 2/3 complex in human non-small cell lung carcinoma.11
316985182020Partial loss of actin nucleator actin-related protein 2/3 activity triggers blebbing in primary T lymphocytes.14
321699002020Proline-rich 11 (PRR11) drives F-actin assembly by recruiting the actin-related protein 2/3 complex in human non-small cell lung carcinoma.11
304892392019Membrane trafficking RNA interference screen identifies a crucial role of the clathrin endocytic pathway and ARP2/3 complex for Japanese encephalitis virus infection in HeLa cells.9
307929692019Phagocytosis of Aspergillus fumigatus by Human Bronchial Epithelial Cells Is Mediated by the Arp2/3 Complex and WIPF2.9
304892392019Membrane trafficking RNA interference screen identifies a crucial role of the clathrin endocytic pathway and ARP2/3 complex for Japanese encephalitis virus infection in HeLa cells.9
307929692019Phagocytosis of Aspergillus fumigatus by Human Bronchial Epithelial Cells Is Mediated by the Arp2/3 Complex and WIPF2.9
296364312018Palladin Compensates for the Arp2/3 Complex and Supports Actin Structures during Listeria Infections.6
300495132018ARP3 promotes tumor metastasis and predicts a poor prognosis in hepatocellular carcinoma.3
296364312018Palladin Compensates for the Arp2/3 Complex and Supports Actin Structures during Listeria Infections.6

Citation

Dessen P

ACTR3 (actin related protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46303/gene-explorer/favicon/favicon-32x32.png