KEAP1 (kelch like ECH associated protein 1)

2007-02-01  

Identity

HGNC
KEAP1
LOCATION
19p13.2
LOCUSID
9817
ALIAS
INrf2,KLHL19
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9817
MIM: 606016
HGNC: 23177
Ensembl: ENSG00000079999

Variants:

dbSNP: 9817
ClinVar: 9817
TCGA: ENSG00000079999
COSMIC: KEAP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000079999ENST00000171111Q14145
ENSG00000079999ENST00000171111A0A024R7C0
ENSG00000079999ENST00000393623Q14145
ENSG00000079999ENST00000393623A0A024R7C0
ENSG00000079999ENST00000585845K7EMY1
ENSG00000079999ENST00000590593K7EPZ3
ENSG00000079999ENST00000591039K7EJ49
ENSG00000079999ENST00000591419K7EJD8
ENSG00000079999ENST00000592055K7ESE0
ENSG00000079999ENST00000592478K7EQX2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381595942024The role of Keap1-Nrf2 signaling pathway during the progress and therapy of diabetic retinopathy.1
381703682024Study of the effect of keap1 on oxidative stress in human umbilical cord mesenchymal stem cells.0
383834792024A tumor suppressor protein encoded by circKEAP1 inhibits osteosarcoma cell stemness and metastasis by promoting vimentin proteasome degradation and activating anti-tumor immunity.1
384792222024GSTP alleviates acute lung injury by S-glutathionylation of KEAP1 and subsequent activation of NRF2 pathway.0
385565462024Ceramide kinase-mediated C1P metabolism attenuates acute liver injury by inhibiting the interaction between KEAP1 and NRF2.1
381595942024The role of Keap1-Nrf2 signaling pathway during the progress and therapy of diabetic retinopathy.1
381703682024Study of the effect of keap1 on oxidative stress in human umbilical cord mesenchymal stem cells.0
383834792024A tumor suppressor protein encoded by circKEAP1 inhibits osteosarcoma cell stemness and metastasis by promoting vimentin proteasome degradation and activating anti-tumor immunity.1
384792222024GSTP alleviates acute lung injury by S-glutathionylation of KEAP1 and subsequent activation of NRF2 pathway.0
385565462024Ceramide kinase-mediated C1P metabolism attenuates acute liver injury by inhibiting the interaction between KEAP1 and NRF2.1
367306182023FXR1 facilitates axitinib resistance in clear cell renal cell carcinoma via regulating KEAP1/Nrf2 signaling pathway.3
369137992023miR-125b-5p in adipose derived stem cells exosome alleviates pulmonary microvascular endothelial cells ferroptosis via Keap1/Nrf2/GPX4 in sepsis lung injury.37
369307852023The KEAP1-NRF2 System and Neurodegenerative Diseases.11
369650712023DDRGK1 Enhances Osteosarcoma Chemoresistance via Inhibiting KEAP1-Mediated NRF2 Ubiquitination.7
371465132023The KEAP1-NRF2 pathway: Targets for therapy and role in cancer.32

Citation

Dessen P

KEAP1 (kelch like ECH associated protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46354/css/card-gene.css