TLR4 (toll like receptor 4)

2007-02-01  

Identity

HGNC
LOCATION
9q33.1
LOCUSID
ALIAS
ARMD10,CD284,TLR-4,TOLL

Other Information

Locus ID:

NCBI: 7099
MIM: 603030
HGNC: 11850
Ensembl: ENSG00000136869

Variants:

dbSNP: 7099
ClinVar: 7099
TCGA: ENSG00000136869
COSMIC: TLR4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136869ENST00000355622O00206
ENSG00000136869ENST00000394487O00206
ENSG00000136869ENST00000472304A0A2R8Y7P4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Toll-like receptor signaling pathwayKEGGko04620
Pathogenic Escherichia coli infectionKEGGko05130
Toll-like receptor signaling pathwayKEGGhsa04620
Pathogenic Escherichia coli infectionKEGGhsa05130
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
LeishmaniasisKEGGko05140
LeishmaniasisKEGGhsa05140
Chagas disease (American trypanosomiasis)KEGGko05142
Chagas disease (American trypanosomiasis)KEGGhsa05142
MalariaKEGGko05144
MalariaKEGGhsa05144
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
AmoebiasisKEGGko05146
AmoebiasisKEGGhsa05146
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
MeaslesKEGGko05162
MeaslesKEGGhsa05162
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Influenza AKEGGko05164
Influenza AKEGGhsa05164
PertussisKEGGko05133
PertussisKEGGhsa05133
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
LegionellosisKEGGko05134
LegionellosisKEGGhsa05134
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Hepatitis BKEGGhsa05161
HIF-1 signaling pathwayKEGGhsa04066
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Inflammatory bowel disease (IBD)KEGGhsa05321
Inflammatory bowel disease (IBD)KEGGko05321
Toll-like receptor signalingKEGGhsa_M00686
Toll-like receptor signalingKEGGM00686
DiseaseREACTOMER-HSA-1643685
Diseases of Immune SystemREACTOMER-HSA-5260271
Diseases associated with the TLR signaling cascadeREACTOMER-HSA-5602358
IRAK4 deficiency (TLR2/4)REACTOMER-HSA-5603041
MyD88 deficiency (TLR2/4)REACTOMER-HSA-5602498
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing-Cross presentationREACTOMER-HSA-1236975
ER-Phagosome pathwayREACTOMER-HSA-1236974
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 3 (TLR3) CascadeREACTOMER-HSA-168164
MyD88-independent TLR3/TLR4 cascadeREACTOMER-HSA-166166
TRIF-mediated TLR3/TLR4 signalingREACTOMER-HSA-937061
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilonREACTOMER-HSA-936964
IKK complex recruitment mediated by RIP1REACTOMER-HSA-937041
TRIF-mediated programmed cell deathREACTOMER-HSA-2562578
TRAF6 mediated induction of TAK1 complexREACTOMER-HSA-937072
Toll Like Receptor 7/8 (TLR7/8) CascadeREACTOMER-HSA-168181
MyD88 dependent cascade initiated on endosomeREACTOMER-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationREACTOMER-HSA-975138
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulationREACTOMER-HSA-975163
Toll Like Receptor 9 (TLR9) CascadeREACTOMER-HSA-168138
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016
Activated TLR4 signallingREACTOMER-HSA-166054
MyD88:Mal cascade initiated on plasma membraneREACTOMER-HSA-166058
Toll Like Receptor 2 (TLR2) CascadeREACTOMER-HSA-181438
Toll Like Receptor TLR1:TLR2 CascadeREACTOMER-HSA-168179
Toll Like Receptor TLR6:TLR2 CascadeREACTOMER-HSA-168188
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Caspase activation via extrinsic apoptotic signalling pathwayREACTOMER-HSA-5357769
Ligand-dependent caspase activationREACTOMER-HSA-140534
Regulation of TLR by endogenous ligandREACTOMER-HSA-5686938

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA133888799Organ TransplantationDiseaseClinicalAnnotationassociatedPK24820765
PA164713160Pertussis vaccinesChemicalClinicalAnnotationassociatedPD17699831, 22383676
PA164713366Tumor necrosis factor alpha (TNF-alpha) inhibitorsChemicalClinicalAnnotationassociatedPD24776844
PA443434Arthritis, RheumatoidDiseaseClinicalAnnotationassociatedPD20136356
PA443796Coronary Artery DiseaseDiseaseClinicalAnnotationassociatedPD12742999
PA446116Inflammatory Bowel DiseasesDiseaseClinicalAnnotationassociatedPD24776844
PA449692folic acidChemicalClinicalAnnotationassociatedPD20136356
PA450428methotrexateChemicalClinicalAnnotationassociatedPD20136356
PA451089pravastatinChemicalClinicalAnnotationassociatedPD12742999
PA451578tacrolimusChemicalClinicalAnnotationassociatedPK24820765

References

Pubmed IDYearTitleCitations
192524802009The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex.646
183048342008LPS/TLR4 signal transduction pathway.642
173846482007Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood.577
200375842010CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.466
182970732008TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta.458
118362572002Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4.388
177671652007Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock.388
178039122007Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran.363
145172782003LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.332
162671052006High mobility group box 1 protein interacts with multiple Toll-like receptors.295

Citation

Dessen P

TLR4 (toll like receptor 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46368/tlr4-(toll-like-receptor-4)