CCT3 (chaperonin containing TCP1 subunit 3)

2007-02-01  

Identity

HGNC
LOCATION
1q22
LOCUSID
ALIAS
CCT-gamma,CCTG,PIG48,TCP-1-gamma,TRIC5
FUSION GENES

Other Information

Locus ID:

NCBI: 7203
MIM: 600114
HGNC: 1616
Ensembl: ENSG00000163468

Variants:

dbSNP: 7203
ClinVar: 7203
TCGA: ENSG00000163468
COSMIC: CCT3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163468ENST00000295688P49368
ENSG00000163468ENST00000368258E9PRN0
ENSG00000163468ENST00000368259P49368
ENSG00000163468ENST00000368262E9PRM9
ENSG00000163468ENST00000413555Q5SZX6
ENSG00000163468ENST00000415548Q5SZX9
ENSG00000163468ENST00000446905Q5SZW8
ENSG00000163468ENST00000472765B4DUR8
ENSG00000163468ENST00000478640E9PM09
ENSG00000163468ENST00000496684E9PRC8
ENSG00000163468ENST00000533194E9PQ35

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Cooperation of Prefoldin and TriC/CCT in actin and tubulin foldingREACTOMER-HSA-389958
Prefoldin mediated transfer of substrate to CCT/TriCREACTOMER-HSA-389957
Formation of tubulin folding intermediates by CCT/TriCREACTOMER-HSA-389960
Folding of actin by CCT/TriCREACTOMER-HSA-390450
Association of TriC/CCT with target proteins during biosynthesisREACTOMER-HSA-390471
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Cargo trafficking to the periciliary membraneREACTOMER-HSA-5620920
BBSome-mediated cargo-targeting to ciliumREACTOMER-HSA-5620922
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta foldingREACTOMER-HSA-6814122

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
191655272009Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.56
125862952003Positional mapping for amplified DNA sequences on 1q21-q22 in hepatocellular carcinoma indicates candidate genes over-expression.24
267390592016Molecular chaperone CCT3 supports proper mitotic progression and cell proliferation in hepatocellular carcinoma cells.20
206348912010Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.18
262294012015Overexpression of chaperonin containing TCP1, subunit 3 predicts poor prognosis in hepatocellular carcinoma.14
238680552013A prospective proteomic-based study for identifying potential biomarkers for the diagnosis of cholangiocarcinoma.8
223995002012Proteomic identification of chaperonin-containing tail-less complex polypeptide-1 gamma subunit as a p53-responsive protein in colon cancer cells.2
318595432020circCCT3 Modulates Vascular Endothelial Growth Factor A and Wnt Signaling to Enhance Colorectal Cancer Metastasis Through Sponging miR-613.1

Citation

Dessen P

CCT3 (chaperonin containing TCP1 subunit 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46436/cct3-(chaperonin-containing-tcp1-subunit-3)