TRIM35 (tripartite motif containing 35)

2007-02-01  

Identity

HGNC
LOCATION
8p21.2
LOCUSID
ALIAS
HLS5,MAIR
FUSION GENES

Other Information

Locus ID:

NCBI: 23087
MIM: 617007
HGNC: 16285
Ensembl: ENSG00000104228

Variants:

dbSNP: 23087
ClinVar: 23087
TCGA: ENSG00000104228
COSMIC: TRIM35

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104228ENST00000305364Q9UPQ4
ENSG00000104228ENST00000521253E5RGB3
ENSG00000104228ENST00000521283H0YBF3

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon gamma signalingREACTOMER-HSA-877300

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
375782392023Inhibition of human adenovirus replication by TRIM35-mediated degradation of E1A.2
375948492023IRF5 promotes glycolysis in the progression of hepatocellular carcinoma and is regulated by TRIM35.1
375782392023Inhibition of human adenovirus replication by TRIM35-mediated degradation of E1A.2
375948492023IRF5 promotes glycolysis in the progression of hepatocellular carcinoma and is regulated by TRIM35.1
350817242022TRIM35 functions as a novel tumor suppressor in breast cancer by inducing cell apoptosis through ubiquitination of PDK1.8
361968942022TRIM35 ubiquitination regulates the expression of PKM2 tetramer and dimer and affects the malignant behaviour of breast cancer by regulating the Warburg effect.7
350817242022TRIM35 functions as a novel tumor suppressor in breast cancer by inducing cell apoptosis through ubiquitination of PDK1.8
361968942022TRIM35 ubiquitination regulates the expression of PKM2 tetramer and dimer and affects the malignant behaviour of breast cancer by regulating the Warburg effect.7
341242762021Suppression of DLBCL Progression by the E3 Ligase Trim35 Is Mediated by CLOCK Degradation and NK Cell Infiltration.5
341242762021Suppression of DLBCL Progression by the E3 Ligase Trim35 Is Mediated by CLOCK Degradation and NK Cell Infiltration.5
322930152020Tripartite motif containing 35 contributes to the proliferation, migration, and invasion of lung cancer cells in vitro and in vivo.4
322930152020Tripartite motif containing 35 contributes to the proliferation, migration, and invasion of lung cancer cells in vitro and in vivo.4
283948822017miR-4417 Targets Tripartite Motif-Containing 35 (TRIM35) and Regulates Pyruvate Kinase Muscle 2 (PKM2) Phosphorylation to Promote Proliferation and Suppress Apoptosis in Hepatocellular Carcinoma Cells.23
283948822017miR-4417 Targets Tripartite Motif-Containing 35 (TRIM35) and Regulates Pyruvate Kinase Muscle 2 (PKM2) Phosphorylation to Promote Proliferation and Suppress Apoptosis in Hepatocellular Carcinoma Cells.23
252634392015TRIM35 Interacts with pyruvate kinase isoform M2 to suppress the Warburg effect and tumorigenicity in hepatocellular carcinoma.41

Citation

Dessen P

TRIM35 (tripartite motif containing 35)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46437/tumors-explorer/cancer-prone-explorer/js/lib/bootstrap.min.js