GIPC1 (GIPC PDZ domain containing family member 1)

2007-02-01  

Identity

HGNC
GIPC1
LOCATION
19p13.12
LOCUSID
10755
ALIAS
C19orf3,GIPC,GLUT1CBP,Hs.6454,IIP-1,NIP,OPDM2,RGS19IP1,SEMCAP,SYNECTIIN,SYNECTIN,TIP-2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10755
MIM: 605072
HGNC: 1226
Ensembl: ENSG00000123159

Variants:

dbSNP: 10755
ClinVar: 10755
TCGA: ENSG00000123159
COSMIC: GIPC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000123159ENST00000345425O14908
ENSG00000123159ENST00000345425A0A024R7I0
ENSG00000123159ENST00000393028O14908
ENSG00000123159ENST00000393028A0A024R7I1
ENSG00000123159ENST00000393033O14908
ENSG00000123159ENST00000393033A0A024R7I0
ENSG00000123159ENST00000586027O14908
ENSG00000123159ENST00000586027A0A024R7I0
ENSG00000123159ENST00000587210K7ESN1
ENSG00000123159ENST00000587934K7ELJ2
ENSG00000123159ENST00000587969K7EIT0
ENSG00000123159ENST00000589497K7EJ33
ENSG00000123159ENST00000589631K7EM11
ENSG00000123159ENST00000591245K7ELJ2
ENSG00000123159ENST00000591349O14908
ENSG00000123159ENST00000591349A0A024R7I1

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
187759912008Endoglin promotes transforming growth factor beta-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC.43
127243272003GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation.39
145079272003GIPC binds to the human lutropin receptor (hLHR) through an unusual PDZ domain binding motif, and it regulates the sorting of the internalized human choriogonadotropin and the density of cell surface hLHR.31
157674242005Human papillomavirus type 18 E6 protein binds the cellular PDZ protein TIP-2/GIPC, which is involved in transforming growth factor beta signaling and triggers its degradation by the proteasome.26
190166552009An essential role for the Glut1 PDZ-binding motif in growth factor regulation of Glut1 degradation and trafficking.26
153562682004GIPC recruits GAIP (RGS19) to attenuate dopamine D2 receptor signaling.23
198554352010Overexpression of myosin VI in prostate cancer cells enhances PSA and VEGF secretion, but has no effect on endocytosis.22
225932122012Endoglin regulates PI3-kinase/Akt trafficking and signaling to alter endothelial capillary stability during angiogenesis.22
267577322016CAPG and GIPC1: Breast Cancer Biomarkers for Bone Metastasis Development and Treatment.22

Citation

Dessen P

GIPC1 (GIPC PDZ domain containing family member 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46448/gipc1