AHRR (aryl-hydrocarbon receptor repressor)

2007-02-01  

Identity

HGNC
AHRR
LOCATION
5p15.33
LOCUSID
57491
ALIAS
AHH,AHHR,bHLHe77
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57491
MIM: 606517
HGNC: 346
Ensembl: ENSG00000286169

Variants:

dbSNP: 57491
ClinVar: 57491
TCGA: ENSG00000286169
COSMIC: AHRR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000286169ENST00000316418A9YTQ3
ENSG00000286169ENST00000505113A9YTQ3
ENSG00000286169ENST00000506909E7EPW6
ENSG00000286169ENST00000512529D6RF73

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Aryl hydrocarbon receptor signallingREACTOMER-HSA-8937144

References

Pubmed IDYearTitleCitations
222320232012Coordinated changes in AHRR methylation in lymphoblasts and pulmonary macrophages from smokers.118
181725542008The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers.77
230706292012Demethylation of the aryl hydrocarbon receptor repressor as a biomarker for nascent smokers.76
242705522014Postnatal stability, tissue, and time specific effects of AHRR methylation change in response to maternal smoking in pregnancy.60
203786152010Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent.40
263070302015DNA Methylation of the Aryl Hydrocarbon Receptor Repressor Associations With Cigarette Smoking and Subclinical Atherosclerosis.34
186766802008Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.32
281007132017AHRR (cg05575921) hypomethylation marks smoking behaviour, morbidity and mortality.32
186327532008Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes.28
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27

Citation

Dessen P

AHRR (aryl-hydrocarbon receptor repressor)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46457/ahrr-(aryl-hydrocarbon-receptor-repressor)