PPIB (peptidylprolyl isomerase B)

2007-02-01 Affiliation

Identity

HGNC

PPIB

LOCATION

15q22.31

LOCUSID

5479

ALIAS

B,CYP-S1,CYPB,HEL-S-39,OI9,SCYLP

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5479
MIM: 123841
HGNC: 9255
Ensembl: ENSG00000166794

Variants:

dbSNP: 5479
ClinVar: 5479
TCGA: ENSG00000166794
COSMIC: PPIB

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000166794	ENST00000300026	P23284

Expression (GTEx)

500

1000

1500

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Extracellular matrix organization	REACTOME	R-HSA-1474244
Collagen formation	REACTOME	R-HSA-1474290
Collagen biosynthesis and modifying enzymes	REACTOME	R-HSA-1650814

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
31634494	2020	Influences of cyclosporin A and non-immunosuppressive derivatives on cellular cyclophilins and viral nucleocapsid protein during human coronavirus 229E replication.	49
32162654	2020	Cyclophilins A and B oppositely regulate renal tubular epithelial cell phenotype.	10
31634494	2020	Influences of cyclosporin A and non-immunosuppressive derivatives on cellular cyclophilins and viral nucleocapsid protein during human coronavirus 229E replication.	49
32162654	2020	Cyclophilins A and B oppositely regulate renal tubular epithelial cell phenotype.	10
30993352	2019	Characterization of PPIB interaction in the P3H1 ternary complex and implications for its pathological mutations.	5
31043353	2019	Cyclophilin B promotes cell proliferation, migration, invasion and angiogenesis via regulating the STAT3 pathway in non-small cell lung cancer.	10
30993352	2019	Characterization of PPIB interaction in the P3H1 ternary complex and implications for its pathological mutations.	5
31043353	2019	Cyclophilin B promotes cell proliferation, migration, invasion and angiogenesis via regulating the STAT3 pathway in non-small cell lung cancer.	10
30430148	2018	A DR4 capturer with AKT siRNA for the synergetic enhancement of death receptor-mediated apoptosis.	2
30430148	2018	A DR4 capturer with AKT siRNA for the synergetic enhancement of death receptor-mediated apoptosis.	2
28242392	2017	Two novel mutations in the PPIB gene cause a rare pedigree of osteogenesis imperfecta type IX.	8
28385890	2017	Ziploc-ing the structure 2.0: Endoplasmic reticulum-resident peptidyl prolyl isomerases show different activities toward hydroxyproline.	9
29146974	2017	Human Cyclophilin B forms part of a multi-protein complex during erythrocyte invasion by Plasmodium falciparum.	11
28242392	2017	Two novel mutations in the PPIB gene cause a rare pedigree of osteogenesis imperfecta type IX.	8
28385890	2017	Ziploc-ing the structure 2.0: Endoplasmic reticulum-resident peptidyl prolyl isomerases show different activities toward hydroxyproline.	9

Citation

Dessen P

PPIB (peptidylprolyl isomerase B)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46463/js/css/favicon/favicon-32x32.png