IL27 (interleukin 27)

2007-02-01  

Identity

HGNC
IL27
LOCATION
16p12.1
LOCUSID
246778
ALIAS
IL-27,IL-27A,IL27A,IL27p28,IL30,p28

Other Information

Locus ID:

NCBI: 246778
MIM: 608273
HGNC: 19157
Ensembl: ENSG00000197272

Variants:

dbSNP: 246778
ClinVar: 246778
TCGA: ENSG00000197272
COSMIC: IL27

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197272ENST00000356897Q8NEV9
ENSG00000197272ENST00000568075H3BQY2

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-6 family signalingREACTOMER-HSA-6783589
IL-6-type cytokine receptor ligand interactionsREACTOMER-HSA-6788467

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
375408942024Research Progress of Interleukin-27 in Inflammatory Bowel Disease.3
382246272024Deletion of IL-27p28 induces CD8 T cell immunity against colorectal tumorigenesis.0
383699032024IL-27 Levels in Bronchoalveolar Lavage Fluid in Children with Post-infectious Bronchiolitis Obliterans.0
383903382024IL-27 alters inflammatory cytokine expression and limits protective immunity against Mycobacterium tuberculosis in a neonatal BCG vaccination model.0
385093692024Role of IL-27 in Epstein-Barr virus infection revealed by IL-27RA deficiency.1
386152362024Association of serum IL-30 and soluble GP130 with the risk of psoriasis vulgaris.0
386902862024The effects of IL-27 and IL-35 gene variation and expression levels on the susceptibility and clinical manifestations of pulmonary tuberculosis.0
389322872024Interleukin 27, Similar to Interferons, Modulates Gene Expression of Tripartite Motif (TRIM) Family Members and Interferes with Mayaro Virus Replication in Human Macrophages.0
375408942024Research Progress of Interleukin-27 in Inflammatory Bowel Disease.3
382246272024Deletion of IL-27p28 induces CD8 T cell immunity against colorectal tumorigenesis.0
383699032024IL-27 Levels in Bronchoalveolar Lavage Fluid in Children with Post-infectious Bronchiolitis Obliterans.0
383903382024IL-27 alters inflammatory cytokine expression and limits protective immunity against Mycobacterium tuberculosis in a neonatal BCG vaccination model.0
385093692024Role of IL-27 in Epstein-Barr virus infection revealed by IL-27RA deficiency.1
386152362024Association of serum IL-30 and soluble GP130 with the risk of psoriasis vulgaris.0
386902862024The effects of IL-27 and IL-35 gene variation and expression levels on the susceptibility and clinical manifestations of pulmonary tuberculosis.0

Citation

Dessen P

IL27 (interleukin 27)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46464/deep-insight-explorer/css/lib/bootstrap.min.css