CD226 (CD226 molecule)

2007-02-01  

Identity

HGNC
CD226
LOCATION
18q22.2
LOCUSID
10666
ALIAS
DNAM-1,DNAM1,PTA1,TLiSA1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10666
MIM: 605397
HGNC: 16961
Ensembl: ENSG00000150637

Variants:

dbSNP: 10666
ClinVar: 10666
TCGA: ENSG00000150637
COSMIC: CD226

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000150637ENST00000280200Q15762
ENSG00000150637ENST00000577287J3QR77
ENSG00000150637ENST00000578928J3QKM7
ENSG00000150637ENST00000579496J3QQW1
ENSG00000150637ENST00000580335J3QL19
ENSG00000150637ENST00000581982J3QR77
ENSG00000150637ENST00000582621Q15762
ENSG00000150637ENST00000583955J3QRQ4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Cell adhesion molecules (CAMs)KEGGhsa04514
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382461702024[Expression of CD226 in the small intestinal group 3 innate lymphoid cells (ILC3) in mice].0
382897062024Essential role of CD155 glycosylation in functional binding to DNAM-1 on natural killer cells.0
384247412024Increased levels of circulating soluble CD226 in multiple sclerosis.0
385922132024Exercise-induced β2-adrenergic Receptor Activation Enhances the Antileukemic Activity of Expanded γδ T-Cells via DNAM-1 Upregulation and PVR/Nectin-2 Recognition.0
382461702024[Expression of CD226 in the small intestinal group 3 innate lymphoid cells (ILC3) in mice].0
382897062024Essential role of CD155 glycosylation in functional binding to DNAM-1 on natural killer cells.0
384247412024Increased levels of circulating soluble CD226 in multiple sclerosis.0
385922132024Exercise-induced β2-adrenergic Receptor Activation Enhances the Antileukemic Activity of Expanded γδ T-Cells via DNAM-1 Upregulation and PVR/Nectin-2 Recognition.0
364406862023NKG2D engagement on human NK cells leads to DNAM-1 hypo-responsiveness through different converging mechanisms.4
370567822023CD226 identifies functional CD8(+)T cells in the tumor microenvironment and predicts a better outcome for human gastric cancer.2
370816682023Decrease in CD226 expression on CD4(+) T cells in patients with endometriosis.1
372441202023Upregulation of CD226 on subsets of T cells and NK cells is associated with upregulated adhesion molecules and cytotoxic factors in patients with tuberculosis.1
374913552023Upregulation of the CD155-CD226 Axis Is Associated With Muscle Inflammation and Disease Severity in Idiopathic Inflammatory Myopathies.0
375962482023TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation.5
376291382023CD155 and Its Receptors as Targets for Cancer Therapy.1

Citation

Dessen P

CD226 (CD226 molecule)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46470/favicon/css/lib/bootstrap.min.css