SLC2A4 (solute carrier family 2 member 4)

2007-02-01  

Identity

HGNC
LOCATION
17p13.1
LOCUSID
ALIAS
GLUT4
FUSION GENES

Other Information

Locus ID:

NCBI: 6517
MIM: 138190
HGNC: 11009
Ensembl: ENSG00000181856

Variants:

dbSNP: 6517
ClinVar: 6517
TCGA: ENSG00000181856
COSMIC: SLC2A4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000181856ENST00000317370P14672
ENSG00000181856ENST00000424875F5H081
ENSG00000181856ENST00000570783I3L1S2
ENSG00000181856ENST00000571308I3L2R4
ENSG00000181856ENST00000572485P14672

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Insulin signaling pathwayKEGGko04910
Adipocytokine signaling pathwayKEGGko04920
Type II diabetes mellitusKEGGko04930
Insulin signaling pathwayKEGGhsa04910
Adipocytokine signaling pathwayKEGGhsa04920
Type II diabetes mellitusKEGGhsa04930
FoxO signaling pathwayKEGGhsa04068
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Translocation of GLUT4 to the plasma membraneREACTOMER-HSA-1445148
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Hexose transportREACTOMER-HSA-189200
Glucose transportREACTOMER-HSA-70153
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Facilitative Na+-independent glucose transportersREACTOMER-HSA-428790
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of white adipocyte differentiationREACTOMER-HSA-381340
Insulin resistanceKEGGhsa04931

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA33744PRKAA1GenePathwayassociated22722338
PA33745PRKAA2GenePathwayassociated22722338
PA33746PRKAB1GenePathwayassociated22722338
PA33747PRKAB2GenePathwayassociated22722338
PA33751PRKAG1GenePathwayassociated22722338
PA33752PRKAG2GenePathwayassociated22722338
PA33753PRKAG3GenePathwayassociated22722338

References

Pubmed IDYearTitleCitations
119947462002Regulated transport of the glucose transporter GLUT4.276
147472782004Strength training increases insulin-mediated glucose uptake, GLUT4 content, and insulin signaling in skeletal muscle in patients with type 2 diabetes.133
162132282005Full intracellular retention of GLUT4 requires AS160 Rab GTPase activating protein.121
181849302008AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5.117
257036772015Insulin resistance and impaired adipogenesis.94
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
126317172003GLUT4 recycles via a trans-Golgi network (TGN) subdomain enriched in Syntaxins 6 and 16 but not TGN38: involvement of an acidic targeting motif.81
145621052003Functional cloning of TUG as a regulator of GLUT4 glucose transporter trafficking.70
211479152011Human cytomegalovirus activates glucose transporter 4 expression to increase glucose uptake during infection.61
126065022003Enhanced basal activation of mitogen-activated protein kinases in adipocytes from type 2 diabetes: potential role of p38 in the downregulation of GLUT4 expression.52

Citation

Dessen P

SLC2A4 (solute carrier family 2 member 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46491/slc2a4