CRP (C-reactive protein)

2007-02-01  

Identity

HGNC
LOCATION
1q23.2
LOCUSID
ALIAS
PTX1
FUSION GENES

Other Information

Locus ID:

NCBI: 1401
MIM: 123260
HGNC: 2367
Ensembl: ENSG00000132693

Variants:

dbSNP: 1401
ClinVar: 1401
TCGA: ENSG00000132693
COSMIC: CRP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132693ENST00000255030P02741
ENSG00000132693ENST00000368110Q5VVP7
ENSG00000132693ENST00000368111Q5VVP7
ENSG00000132693ENST00000368112P02741
ENSG00000132693ENST00000437342C9JRE9

Expression (GTEx)

0
1000
2000
3000
4000
5000
6000

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Complement cascadeREACTOMER-HSA-166658
Initial triggering of complementREACTOMER-HSA-166663
Creation of C4 and C2 activatorsREACTOMER-HSA-166786
Classical antibody-mediated complement activationREACTOMER-HSA-173623

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10004adalimumabChemicalClinicalAnnotationassociatedPD27096233
PA134308647rosuvastatinChemicalClinicalAnnotationassociatedPKPD21094359
PA162370415Metabolic SyndromeDiseaseClinicalAnnotationassociatedPD
PA443797Coronary DiseaseDiseaseClinicalAnnotationassociatedPKPD21094359
PA447216SchizophreniaDiseaseMultilinkAnnotationassociated27327646
PA449594fenofibrateChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
191885312009Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis.670
153377542004C-reactive Protein.264
117393012001C-reactive protein elevation in patients with atrial arrhythmias: inflammatory mechanisms and persistence of atrial fibrillation.260
159553852005Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-alpha and IL-6.197
189714922008Genetically elevated C-reactive protein and ischemic vascular disease.188
189714922008Genetically elevated C-reactive protein and ischemic vascular disease.188
189971942008C-reactive protein and parental history improve global cardiovascular risk prediction: the Reynolds Risk Score for men.186
184649132008A genome-wide association study identifies protein quantitative trait loci (pQTLs).184
195674382009Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease.180
213250052011Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data.167

Citation

Dessen P

CRP (C-reactive protein)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46502/crp