IAPP (islet amyloid polypeptide)

2007-02-01  

Identity

HGNC
IAPP
LOCATION
12p12.1
LOCUSID
3375
ALIAS
DAP,IAP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3375
MIM: 147940
HGNC: 5329
Ensembl: ENSG00000121351

Variants:

dbSNP: 3375
ClinVar: 3375
TCGA: ENSG00000121351
COSMIC: IAPP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121351ENST00000240652P10997
ENSG00000121351ENST00000240652A0A024RAU1
ENSG00000121351ENST00000535428H0YF85
ENSG00000121351ENST00000537593F5H0S1
ENSG00000121351ENST00000539393P10997
ENSG00000121351ENST00000539393A0A024RAU1
ENSG00000121351ENST00000542023F5H1F0

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Maturity onset diabetes of the youngKEGGko04950
Maturity onset diabetes of the youngKEGGhsa04950
Metabolism of proteinsREACTOMER-HSA-392499
Amyloid fiber formationREACTOMER-HSA-977225
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Calcitonin-like ligand receptorsREACTOMER-HSA-419812
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555
Developmental BiologyREACTOMER-HSA-1266738
Regulation of beta-cell developmentREACTOMER-HSA-186712
Regulation of gene expression in beta cellsREACTOMER-HSA-210745

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383387962024Amylin, Another Important Neuroendocrine Hormone for the Treatment of Diabesity.0
386045262024The Co-oligomers of Aβ42 and Human Islet Amyloid Polypeptide Exacerbate Neurotoxicity and Alzheimer-like Pathology at Cellular Level.0
383387962024Amylin, Another Important Neuroendocrine Hormone for the Treatment of Diabesity.0
386045262024The Co-oligomers of Aβ42 and Human Islet Amyloid Polypeptide Exacerbate Neurotoxicity and Alzheimer-like Pathology at Cellular Level.0
366715532023Novel Hominid-Specific IAPP Isoforms: Potential Biomarkers of Early Alzheimer's Disease and Inhibitors of Amyloid Formation.0
368351872023Plasma IAPP-Autoantibody Levels in Alzheimer's Disease Patients Are Affected by APOE4 Status.1
368983492023Lipid domain boundary triggers membrane damage and protein folding of human islet amyloid polypeptide in the early pathogenesis of amyloid diseases.4
371213652023Impact of Ca(2+) on membrane catalyzed IAPP amyloid formation and IAPP induced vesicle leakage.0
371267822023Interspecies Variation Affects Islet Amyloid Polypeptide Membrane Binding.2
377624252023The Aβ42 Peptide and IAPP Physically Interact in a Yeast-Based Assay.1
366715532023Novel Hominid-Specific IAPP Isoforms: Potential Biomarkers of Early Alzheimer's Disease and Inhibitors of Amyloid Formation.0
368351872023Plasma IAPP-Autoantibody Levels in Alzheimer's Disease Patients Are Affected by APOE4 Status.1
368983492023Lipid domain boundary triggers membrane damage and protein folding of human islet amyloid polypeptide in the early pathogenesis of amyloid diseases.4
371213652023Impact of Ca(2+) on membrane catalyzed IAPP amyloid formation and IAPP induced vesicle leakage.0
371267822023Interspecies Variation Affects Islet Amyloid Polypeptide Membrane Binding.2

Citation

Dessen P

IAPP (islet amyloid polypeptide)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46516/gene-fusions-explorer/js/lib/css/template-card.css