SIRT2 (sirtuin 2)

2007-02-01  

Identity

HGNC
LOCATION
19q13.2
LOCUSID
ALIAS
SIR2,SIR2L,SIR2L2
FUSION GENES

Other Information

Locus ID:

NCBI: 22933
MIM: 604480
HGNC: 10886
Ensembl: ENSG00000068903

Variants:

dbSNP: 22933
ClinVar: 22933
TCGA: ENSG00000068903
COSMIC: SIRT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000068903ENST00000249396Q8IXJ6
ENSG00000068903ENST00000358931A0A0A0MRF5
ENSG00000068903ENST00000381766C9JZQ0
ENSG00000068903ENST00000392081Q8IXJ6
ENSG00000068903ENST00000392081A0A024R0G8
ENSG00000068903ENST00000407552B5MCS1
ENSG00000068903ENST00000414941E7EWX6
ENSG00000068903ENST00000420440F8WCF4
ENSG00000068903ENST00000423526F8WDM4
ENSG00000068903ENST00000437828C9J3U7
ENSG00000068903ENST00000443898F8WBT6
ENSG00000068903ENST00000447739C9JR33
ENSG00000068903ENST00000451193F8WF57
ENSG00000068903ENST00000613542A0A087WYM3

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA131301952gefitinibChemicalClinicalAnnotationassociatedPD31664190
PA164925725Toxic liver diseaseDiseaseClinicalAnnotationassociatedPD31664190

References

Pubmed IDYearTitleCitations
126202312003The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase.490
128878922003Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state.207
205438402010Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity.193
166484622006SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis.191
153285402004Sir2-independent life span extension by calorie restriction in yeast.168
126978182003Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle.157
182491702008Conserved metabolic regulatory functions of sirtuins.157
203788382010SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis.100
177265142007Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis.91
223029382012Dietary obesity-associated Hif1α activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ system.90

Citation

Dessen P

SIRT2 (sirtuin 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46529/sirt2-(sirtuin-2)