TIA1 (TIA1 cytotoxic granule associated RNA binding protein)

2007-02-01  

Identity

HGNC
TIA1
LOCATION
2p13.3
LOCUSID
7072
ALIAS
ALS26,TIA-1,WDM
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7072
MIM: 603518
HGNC: 11802
Ensembl: ENSG00000116001

Variants:

dbSNP: 7072
ClinVar: 7072
TCGA: ENSG00000116001
COSMIC: TIA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116001ENST00000282574F8W8I6
ENSG00000116001ENST00000361692H7BY49
ENSG00000116001ENST00000415783P31483
ENSG00000116001ENST00000416149P31483
ENSG00000116001ENST00000433529P31483
ENSG00000116001ENST00000445587C9JTN7
ENSG00000116001ENST00000454815F8WE16
ENSG00000116001ENST00000474809E5RGV5
ENSG00000116001ENST00000477044E5RG67

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by FGFRREACTOMER-HSA-190236
Signaling by FGFR2REACTOMER-HSA-5654738
FGFR2 alternative splicingREACTOMER-HSA-6803529

References

Pubmed IDYearTitleCitations
388583552024The miR-30-5p/TIA-1 axis directs cellular senescence by regulating mitochondrial dynamics.0
388583552024The miR-30-5p/TIA-1 axis directs cellular senescence by regulating mitochondrial dynamics.0
373493292023Mutagenesis and structural studies reveal the basis for the specific binding of SARS-CoV-2 SL3 RNA element with human TIA1 protein.3
380168752023Distal myopathy due to digenic inheritance of TIA1 and SQSTM1 variants in two unrelated Spanish patients.0
382795012023RAMP2-AS1 stabilized RAPM2 mRNA through TIA1 to inhibit the progression of non-small cell lung cancer.0
373493292023Mutagenesis and structural studies reveal the basis for the specific binding of SARS-CoV-2 SL3 RNA element with human TIA1 protein.3
380168752023Distal myopathy due to digenic inheritance of TIA1 and SQSTM1 variants in two unrelated Spanish patients.0
382795012023RAMP2-AS1 stabilized RAPM2 mRNA through TIA1 to inhibit the progression of non-small cell lung cancer.0
347509822022Amyotrophic lateral sclerosis (ALS) linked mutation in Ubiquilin 2 affects stress granule assembly via TIA-1.9
351633202022The Multifunctional Faces of T-Cell Intracellular Antigen 1 in Health and Disease.6
357992932022Intracellular accumulation of tau inhibits autophagosome formation by activating TIA1-amino acid-mTORC1 signaling.6
358723672022The role of peritumoral CD8 + /TIA1 + lymphocytes in hepatocellular carcinoma aggressiveness and recurrence after surgical resection.0
361126472022ALS mutations in the TIA-1 prion-like domain trigger highly condensed pathogenic structures.6
347509822022Amyotrophic lateral sclerosis (ALS) linked mutation in Ubiquilin 2 affects stress granule assembly via TIA-1.9
351633202022The Multifunctional Faces of T-Cell Intracellular Antigen 1 in Health and Disease.6

Citation

Dessen P

TIA1 (TIA1 cytotoxic granule associated RNA binding protein)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46551/gene-fusions-explorer/haematological-explorer/favicon/apple-touch-icon.png