IRF3 (interferon regulatory factor 3)

2007-02-01 Affiliation

Identity

HGNC

IRF3

LOCATION

19q13.33

LOCUSID

3661

ALIAS

IIAE7

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3661
MIM: 603734
HGNC: 6118
Ensembl: ENSG00000126456

Variants:

dbSNP: 3661
ClinVar: 3661
TCGA: ENSG00000126456
COSMIC: IRF3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000126456	ENST00000309877	Q14653
ENSG00000126456	ENST00000377135	M0QYT9
ENSG00000126456	ENST00000377139	Q14653
ENSG00000126456	ENST00000442265	Q14653
ENSG00000126456	ENST00000593337	M0R3E9
ENSG00000126456	ENST00000593818	M0R0X9
ENSG00000126456	ENST00000593922	M0QYT9
ENSG00000126456	ENST00000595034	M0QXC8
ENSG00000126456	ENST00000596756	M0R3C2
ENSG00000126456	ENST00000596765	Q14653
ENSG00000126456	ENST00000596788	M0R3H7
ENSG00000126456	ENST00000596822	M0QX56
ENSG00000126456	ENST00000597198	Q14653
ENSG00000126456	ENST00000597636	M0QZB8
ENSG00000126456	ENST00000598108	M0R205
ENSG00000126456	ENST00000598808	M0QYT9
ENSG00000126456	ENST00000599144	M0QYT9
ENSG00000126456	ENST00000599223	Q14653
ENSG00000126456	ENST00000600022	Q14653
ENSG00000126456	ENST00000600453	M0R007
ENSG00000126456	ENST00000600911	M0QZB7
ENSG00000126456	ENST00000601291	Q14653
ENSG00000126456	ENST00000601373	M0R0R8
ENSG00000126456	ENST00000601809	M0QYX3

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Toll-like receptor signaling pathway	KEGG	ko04620
Toll-like receptor signaling pathway	KEGG	hsa04620
RIG-I-like receptor signaling pathway	KEGG	ko04622
RIG-I-like receptor signaling pathway	KEGG	hsa04622
NOD-like receptor signaling pathway	KEGG	ko04621
NOD-like receptor signaling pathway	KEGG	hsa04621
Cytosolic DNA-sensing pathway	KEGG	ko04623
Cytosolic DNA-sensing pathway	KEGG	hsa04623
Hepatitis C	KEGG	ko05160
Hepatitis C	KEGG	hsa05160
Measles	KEGG	ko05162
Measles	KEGG	hsa05162
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
Pertussis	KEGG	ko05133
Pertussis	KEGG	hsa05133
Herpes simplex infection	KEGG	ko05168
Herpes simplex infection	KEGG	hsa05168
Epstein-Barr virus infection	KEGG	hsa05169
Epstein-Barr virus infection	KEGG	ko05169
Viral carcinogenesis	KEGG	hsa05203
Viral carcinogenesis	KEGG	ko05203
Hepatitis B	KEGG	hsa05161
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Toll-Like Receptors Cascades	REACTOME	R-HSA-168898
Toll Like Receptor 3 (TLR3) Cascade	REACTOME	R-HSA-168164
MyD88-independent TLR3/TLR4 cascade	REACTOME	R-HSA-166166
TRIF-mediated TLR3/TLR4 signaling	REACTOME	R-HSA-937061
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	REACTOME	R-HSA-936964
Toll Like Receptor 4 (TLR4) Cascade	REACTOME	R-HSA-166016
Activated TLR4 signalling	REACTOME	R-HSA-166054
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways	REACTOME	R-HSA-168928
TRAF3-dependent IRF activation pathway	REACTOME	R-HSA-918233
TRAF6 mediated IRF7 activation	REACTOME	R-HSA-933541
Negative regulators of RIG-I/MDA5 signaling	REACTOME	R-HSA-936440
Cytosolic sensors of pathogen-associated DNA	REACTOME	R-HSA-1834949
ZBP1(DAI) mediated induction of type I IFNs	REACTOME	R-HSA-1606322
IRF3 mediated activation of type 1 IFN	REACTOME	R-HSA-1606341
STING mediated induction of host immune responses	REACTOME	R-HSA-1834941
IRF3-mediated induction of type I IFN	REACTOME	R-HSA-3270619
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	REACTOME	R-HSA-3134973
Regulation of innate immune responses to cytosolic DNA	REACTOME	R-HSA-3134975
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Interferon Signaling	REACTOME	R-HSA-913531
Interferon alpha/beta signaling	REACTOME	R-HSA-909733
Interferon gamma signaling	REACTOME	R-HSA-877300
Antiviral mechanism by IFN-stimulated genes	REACTOME	R-HSA-1169410
ISG15 antiviral mechanism	REACTOME	R-HSA-1169408
Hemostasis	REACTOME	R-HSA-109582
Factors involved in megakaryocyte development and platelet production	REACTOME	R-HSA-983231

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA164722208	MAVS	Gene	Pathway	associated			26111151

References

Pubmed ID	Year	Title	Citations
12692549	2003	IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.	833
18818105	2008	The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation.	428
14517278	2003	LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.	332
25636800	2015	Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.	308
19701189	2009	Activation of innate immune antiviral responses by Nod2.	279
12354379	2002	IRF3 mediates a TLR3/TLR4-specific antiviral gene program.	275
22394562	2012	STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway.	261
12829834	2003	The Ebola virus VP35 protein inhibits activation of interferon regulatory factor 3.	216
16585524	2006	Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection.	194
23027953	2012	Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein.	192

Citation

Dessen P

IRF3 (interferon regulatory factor 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46567/irf3