TLR10 (toll like receptor 10)

2007-02-01  

Identity

HGNC
LOCATION
4p14
LOCUSID
ALIAS
CD290

Other Information

Locus ID:

NCBI: 81793
MIM: 606270
HGNC: 15634
Ensembl: ENSG00000174123

Variants:

dbSNP: 81793
ClinVar: 81793
TCGA: ENSG00000174123
COSMIC: TLR10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174123ENST00000308973Q9BXR5
ENSG00000174123ENST00000308973A0A024R9W4
ENSG00000174123ENST00000361424Q9BXR5
ENSG00000174123ENST00000361424A0A024R9W4
ENSG00000174123ENST00000502321D6RHW6
ENSG00000174123ENST00000506111Q9BXR5
ENSG00000174123ENST00000506111A0A024R9W4
ENSG00000174123ENST00000508334Q9BXR5
ENSG00000174123ENST00000508334A0A024R9W4
ENSG00000174123ENST00000613579Q9BXR5
ENSG00000174123ENST00000613579A0A024R9W4
ENSG00000174123ENST00000622002Q9BXR5
ENSG00000174123ENST00000622002A0A024R9W4

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Diseases of Immune SystemREACTOMER-HSA-5260271
Diseases associated with the TLR signaling cascadeREACTOMER-HSA-5602358
IRAK4 deficiency (TLR5)REACTOMER-HSA-5603037
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 10 (TLR10) CascadeREACTOMER-HSA-168142
MyD88 cascade initiated on plasma membraneREACTOMER-HSA-975871
Toll Like Receptor 5 (TLR5) CascadeREACTOMER-HSA-168176

References

Pubmed IDYearTitleCitations
126899442003The toll-like receptor repertoire of human B lymphocytes: inducible and selective expression of TLR9 and TLR10 in normal and transformed cells.113
157285062005Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88.109
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
203484272010Human TLRs 10 and 1 share common mechanisms of innate immune sensing but not signaling.79
180919912007Full-exon resequencing reveals toll-like receptor variants contribute to human susceptibility to tuberculosis disease.75
183321492008The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer.74
252887452014Human TLR10 is an anti-inflammatory pattern-recognition receptor.70
245673772014Toll-like receptor 10 is involved in induction of innate immune responses to influenza virus infection.51
185476252008Toll-like receptor heterodimer variants protect from childhood asthma.46
192476922009Analyses of associations with asthma in four asthma population samples from Canada and Australia.39

Citation

Dessen P

TLR10 (toll like receptor 10)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46568/tlr10-(toll-like-receptor-10)