AURKAIP1 (aurora kinase A interacting protein 1)

2007-03-01  

Identity

HGNC
LOCATION
1p36.33
LOCUSID
ALIAS
AIP,AKIP,MRP-S38
FUSION GENES

Other Information

Locus ID:

NCBI: 54998
MIM: 609183
HGNC: 24114
Ensembl: ENSG00000175756

Variants:

dbSNP: 54998
ClinVar: 54998
TCGA: ENSG00000175756
COSMIC: AURKAIP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000175756ENST00000321751Q9NWT8
ENSG00000175756ENST00000321751A0A024R0F0
ENSG00000175756ENST00000338338Q9NWT8
ENSG00000175756ENST00000338338A0A024R0F0
ENSG00000175756ENST00000338370Q9NWT8
ENSG00000175756ENST00000338370A0A024R0F0
ENSG00000175756ENST00000378853Q9NWT8
ENSG00000175756ENST00000378853A0A024R0F0

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Mitochondrial translationREACTOMER-HSA-5368287
Mitochondrial translation initiationREACTOMER-HSA-5368286
Mitochondrial translation elongationREACTOMER-HSA-5389840
Mitochondrial translation terminationREACTOMER-HSA-5419276

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
185216202008Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora.61
223568262012Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase.32
174529722007Antizyme1 mediates AURKAIP1-dependent degradation of Aurora-A.31
192215042009The inhibition of Aurora A abrogates the mitotic delay induced by microtubule perturbing agents.25
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
152718562004Functional Phe31Ile polymorphism in Aurora A and risk of breast carcinoma.14
183919812008AIP regulates stability of Aurora-A at early mitotic phase coordinately with GSK-3beta.11
219329832011Capsaicin induces apoptosis of cisplatin-resistant stomach cancer cells by causing degradation of cisplatin-inducible Aurora-A protein.8
122440512002Aurora-A kinase interacting protein (AIP), a novel negative regulator of human Aurora-A kinase.7
179577262007Aurora-A kinase phosphorylation of Aurora-A kinase interacting protein (AIP) and stabilization of the enzyme-substrate complex.3

Citation

Dessen P

AURKAIP1 (aurora kinase A interacting protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-03-01

Online version: http://atlasgeneticsoncology.org/gene/46620/aurkaip1-(aurora-kinase-a-interacting-protein-1)