APOBEC3G (apolipoprotein B mRNA editing enzyme catalytic subunit 3G)

2007-03-01  

Identity

HGNC
LOCATION
22q13.1
LOCUSID
ALIAS
A3G,ARCD,ARP-9,ARP9,CEM-15,CEM15,MDS019,bK150C2.7,dJ494G10.1
FUSION GENES

Other Information

Locus ID:

NCBI: 60489
MIM: 607113
HGNC: 17357
Ensembl: ENSG00000239713

Variants:

dbSNP: 60489
ClinVar: 60489
TCGA: ENSG00000239713
COSMIC: APOBEC3G

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000239713ENST00000407997Q9HC16

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
Host Interactions of HIV factorsREACTOMER-HSA-162909
APOBEC3G mediated resistance to HIV-1 infectionREACTOMER-HSA-180689
Vif-mediated degradation of APOBEC3GREACTOMER-HSA-180585

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
121678632002Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein.1077
128084662003Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts.694
145640142003Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex.579
128084652003The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA.516
145274062003HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability.343
146729282004Vif overcomes the innate antiviral activity of APOBEC3G by promoting its degradation in the ubiquitin-proteasome pathway.248
152697862004Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G.230
150314972004Inhibition of hepatitis B virus replication by APOBEC3G.191
190576632008APOBEC3G inhibits elongation of HIV-1 reverse transcripts.178
195870572009Defining APOBEC3 expression patterns in human tissues and hematopoietic cell subsets.176

Citation

Dessen P

APOBEC3G (apolipoprotein B mRNA editing enzyme catalytic subunit 3G)

Atlas Genet Cytogenet Oncol Haematol. 2007-03-01

Online version: http://atlasgeneticsoncology.org/gene/46621/gc-apobec3g