FOLR2 (folate receptor beta)

2007-04-01  

Identity

HGNC
FOLR2
LOCATION
11q13.4
LOCUSID
2350
ALIAS
BETA-HFR,FBP,FBP/PL-1,FOLR1,FR-BETA,FR-P3,FRbeta
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2350
MIM: 136425
HGNC: 3793
Ensembl: ENSG00000165457

Variants:

dbSNP: 2350
ClinVar: 2350
TCGA: ENSG00000165457
COSMIC: FOLR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165457ENST00000298223P14207
ENSG00000165457ENST00000321324E7EU04
ENSG00000165457ENST00000449475J3KQP4
ENSG00000165457ENST00000454954J3KR13
ENSG00000165457ENST00000535625F5H4Z6
ENSG00000165457ENST00000536778F5H3Z4
ENSG00000165457ENST00000538353F5GXV3
ENSG00000165457ENST00000539412F5GZ45
ENSG00000165457ENST00000541003F5H5L8
ENSG00000165457ENST00000619261A0A087WWY2

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Post-translational modification: synthesis of GPI-anchored proteinsREACTOMER-HSA-163125
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Metabolism of folate and pterinesREACTOMER-HSA-196757
Antifolate resistanceKEGGko01523
Antifolate resistanceKEGGhsa01523

References

Pubmed IDYearTitleCitations
381667562024microRNA-622 upregulates cell cycle process by targeting FOLR2 to promote CRC proliferation.0
381667562024microRNA-622 upregulates cell cycle process by targeting FOLR2 to promote CRC proliferation.0
378837282023Mutational analysis of FOLR1 and FOLR2 genes in children with Myelomeningocele.0
378837282023Mutational analysis of FOLR1 and FOLR2 genes in children with Myelomeningocele.0
351859102022Folate Receptor Beta for Macrophage Imaging in Rheumatoid Arthritis.7
352557272022Folate Receptor Expression by Human Monocyte-Derived Macrophage Subtypes and Effects of Corticosteroids.5
353944842022FOLR2+ Macrophages Are Associated with T-cell Infiltration and Improved Prognosis.1
355453632022Association of periconceptional folate supplements and FOLR1 and FOLR2 gene polymorphisms with risk of congenital heart disease in offspring: A hospital-based case-control study.0
351859102022Folate Receptor Beta for Macrophage Imaging in Rheumatoid Arthritis.7
352557272022Folate Receptor Expression by Human Monocyte-Derived Macrophage Subtypes and Effects of Corticosteroids.5
353944842022FOLR2+ Macrophages Are Associated with T-cell Infiltration and Improved Prognosis.1
355453632022Association of periconceptional folate supplements and FOLR1 and FOLR2 gene polymorphisms with risk of congenital heart disease in offspring: A hospital-based case-control study.0
340703692021Folate Receptor Beta as a Direct and Indirect Target for Antibody-Based Cancer Immunotherapy.9
347551342021Targeting folate receptor beta on monocytes/macrophages renders rapid inflammation resolution independent of root causes.7
340703692021Folate Receptor Beta as a Direct and Indirect Target for Antibody-Based Cancer Immunotherapy.9

Citation

Dessen P

FOLR2 (folate receptor beta)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46634/js/lib/zoomerang.js