UBE2G2 (ubiquitin conjugating enzyme E2 G2)

2007-04-01  

Identity

HGNC
LOCATION
21q22.3
LOCUSID
ALIAS
UBC7
FUSION GENES

Other Information

Locus ID:

NCBI: 7327
MIM: 603124
HGNC: 12483
Ensembl: ENSG00000184787

Variants:

dbSNP: 7327
ClinVar: 7327
TCGA: ENSG00000184787
COSMIC: UBE2G2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184787ENST00000330942P60604
ENSG00000184787ENST00000345496P60604
ENSG00000184787ENST00000478200F8WDB1
ENSG00000184787ENST00000491513F8WCB9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Parkinson's diseaseKEGGhsa05012
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Protein ubiquitinationREACTOMER-HSA-8852135
Synthesis of active ubiquitin: roles of E1 and E2 enzymesREACTOMER-HSA-8866652

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
164071622006The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding site.105
211270632011Ancient ubiquitous protein 1 (AUP1) localizes to lipid droplets and binds the E2 ubiquitin conjugase G2 (Ube2g2) via its G2 binding region.39
243669452014Dimeric Ube2g2 simultaneously engages donor and acceptor ubiquitins to form Lys48-linked ubiquitin chains.21
128695712003Inositol 1,4,5-trisphosphate receptor ubiquitination is mediated by mammalian Ubc7, a component of the endoplasmic reticulum-associated degradation pathway, and is inhibited by chelation of intracellular Zn2+.17
200140272010Solution structure and dynamics of human ubiquitin conjugating enzyme Ube2g2.15
165824782006Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7).13
210980182011Mechanism of polyubiquitin chain recognition by the human ubiquitin conjugating enzyme Ube2g2.5
287437402017Multiple E2 ubiquitin-conjugating enzymes regulate human cytomegalovirus US2-mediated immunoreceptor downregulation.4
270670472016The linkage specificity determination of Ube2g2-gp78 mediated polyubiquitination.1

Citation

Dessen P

UBE2G2 (ubiquitin conjugating enzyme E2 G2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46647/ube2g2