FBP1 (fructose-bisphosphatase 1)

2007-04-01  

Identity

HGNC
LOCATION
9q22.32
LOCUSID
ALIAS
FBP
FUSION GENES

Other Information

Locus ID:

NCBI: 2203
MIM: 611570
HGNC: 3606
Ensembl: ENSG00000165140

Variants:

dbSNP: 2203
ClinVar: 2203
TCGA: ENSG00000165140
COSMIC: FBP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165140ENST00000375326P09467
ENSG00000165140ENST00000414122Q5VZC3
ENSG00000165140ENST00000415431P09467
ENSG00000165140ENST00000648117A0A3B3IUC7

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Glycolysis / GluconeogenesisKEGGko00010
Pentose phosphate pathwayKEGGko00030
Fructose and mannose metabolismKEGGko00051
Insulin signaling pathwayKEGGko04910
Glycolysis / GluconeogenesisKEGGhsa00010
Pentose phosphate pathwayKEGGhsa00030
Fructose and mannose metabolismKEGGhsa00051
Insulin signaling pathwayKEGGhsa04910
Metabolic pathwaysKEGGhsa01100
Gluconeogenesis, oxaloacetate => fructose-6PKEGGhsa_M00003
Gluconeogenesis, oxaloacetate => fructose-6PKEGGM00003
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
Glucagon signaling pathwayKEGGhsa04922
Glucagon signaling pathwayKEGGko04922
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glucose metabolismREACTOMER-HSA-70326
GluconeogenesisREACTOMER-HSA-70263

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
250430302014Fructose-1,6-bisphosphatase opposes renal carcinoma progression.158
198815512010Warburg effect revisited: an epigenetic link between glycolysis and gastric carcinogenesis.69
220394172011Promoter hypermethylation mediated downregulation of FBP1 in human hepatocellular carcinoma and colon cancer.49
271971512016Decreased Expression of Fructose-1,6-bisphosphatase Associates with Glucose Metabolism and Tumor Progression in Hepatocellular Carcinoma.35
293770042018Antagonism of PPAR-γ signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis.28
186604892008Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.26
260689812015NPM1 activates metabolic changes by inhibiting FBP1 while promoting the tumorigenicity of pancreatic cancer cells.26
189786782008Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts.21
237553052013Suppression of gluconeogenic gene expression by LSD1-mediated histone demethylation.19
265460812016Down-regulation of FBP1 by ZEB1-mediated repression confers to growth and invasion in lung cancer cells.16

Citation

Dessen P

FBP1 (fructose-bisphosphatase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46648/fbp1-(fructose-bisphosphatase-1)