CCNB3 (cyclin B3)

CCNB3 (cyclin B3)

2007-04-01 Affiliation

Identity

HGNC

LOCATION

Xp11.22

LOCUSID

ALIAS

CYCB3

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 85417
MIM: 300456
HGNC: 18709
Ensembl: ENSG00000147082

Variants:

dbSNP: 85417
ClinVar: 85417
TCGA: ENSG00000147082
COSMIC: CCNB3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000147082	ENST00000276014	Q8WWL7
ENSG00000147082	ENST00000348603	Q8WWL7
ENSG00000147082	ENST00000376038	Q8WWL7
ENSG00000147082	ENST00000376042	Q8WWL7
ENSG00000147082	ENST00000476167	Q8WWL7

Expression (GTEx)

0

5

10

15

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cell cycle	KEGG	ko04110
p53 signaling pathway	KEGG	ko04115
Progesterone-mediated oocyte maturation	KEGG	ko04914
Cell cycle	KEGG	hsa04110
p53 signaling pathway	KEGG	hsa04115
Progesterone-mediated oocyte maturation	KEGG	hsa04914
FoxO signaling pathway	KEGG	hsa04068
Cell cycle - G2/M transition	KEGG	hsa_M00693
Cell cycle - G2/M transition	KEGG	M00693

References

Pubmed ID	Year	Title	Citations
36791667	2023	A global collaboRAtive study of CIC-rearranged, BCOR::CCNB3-rearranged and other ultra-rare unclassified undifferentiated small round cell sarcomas (GRACefUl).	6
37635245	2023	Mutations in CCNB3 affect its location thus causing a multiplicity of phenotypes in human oocytes maturation by aberrant CDK1 activity and APC/C activity at different stages.	1
36791667	2023	A global collaboRAtive study of CIC-rearranged, BCOR::CCNB3-rearranged and other ultra-rare unclassified undifferentiated small round cell sarcomas (GRACefUl).	6
37635245	2023	Mutations in CCNB3 affect its location thus causing a multiplicity of phenotypes in human oocytes maturation by aberrant CDK1 activity and APC/C activity at different stages.	1
32840647	2021	Imaging features and clinical course of undifferentiated round cell sarcomas with CIC-DUX4 and BCOR-CCNB3 translocations.	7
32938693	2021	Biallelic variant in cyclin B3 is associated with failure of maternal meiosis II and recurrent digynic triploidy.	4
32840647	2021	Imaging features and clinical course of undifferentiated round cell sarcomas with CIC-DUX4 and BCOR-CCNB3 translocations.	7
32938693	2021	Biallelic variant in cyclin B3 is associated with failure of maternal meiosis II and recurrent digynic triploidy.	4
31876361	2020	BCOR-CCNB3 fusion-positive clear cell sarcoma of the kidney.	5
31876361	2020	BCOR-CCNB3 fusion-positive clear cell sarcoma of the kidney.	5
30064235	2018	An undifferentiated sarcoma with BCOR-CCNB3 fusion transcript - pathological and clinical retrospective study.	4
30064235	2018	An undifferentiated sarcoma with BCOR-CCNB3 fusion transcript - pathological and clinical retrospective study.	4
28817404	2017	Primary Renal Sarcomas With BCOR-CCNB3 Gene Fusion: A Report of 2 Cases Showing Histologic Overlap With Clear Cell Sarcoma of Kidney, Suggesting Further Link Between BCOR-related Sarcomas of the Kidney and Soft Tissues.	26
28877060	2017	Clinicopathologic Diversity of Undifferentiated Sarcoma With BCOR-CCNB3 Fusion: Analysis of 11 Cases With a Reappraisal of the Utility of Immunohistochemistry for BCOR and CCNB3.	20
28817404	2017	Primary Renal Sarcomas With BCOR-CCNB3 Gene Fusion: A Report of 2 Cases Showing Histologic Overlap With Clear Cell Sarcoma of Kidney, Suggesting Further Link Between BCOR-related Sarcomas of the Kidney and Soft Tissues.	26

Citation

Dessen P

CCNB3 (cyclin B3)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46654/case-report-explorer/cancer-prone-explorer/js/template.js