HECTD2 (HECT domain E3 ubiquitin protein ligase 2)

2007-04-01 Affiliation

Identity

HGNC

HECTD2

LOCATION

10q23.32

LOCUSID

143279

ALIAS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 143279
HGNC: 26736
Ensembl: ENSG00000165338

Variants:

dbSNP: 143279
ClinVar: 143279
TCGA: ENSG00000165338
COSMIC: HECTD2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000165338	ENST00000298068	Q5U5R9
ENSG00000165338	ENST00000371667	X6R824
ENSG00000165338	ENST00000371681	Q5U5R9
ENSG00000165338	ENST00000446394	E7ERR3
ENSG00000165338	ENST00000631422	A0A0J9YVV1

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Class I MHC mediated antigen processing & presentation	REACTOME	R-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradation	REACTOME	R-HSA-983168

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
38688591	2024	HECTD2/TNFAIP1 Axis Regulating the p38/JNK Pathway to Promote an Inflammatory Response in Renal Cell Carcinoma Cells.	0
38688591	2024	HECTD2/TNFAIP1 Axis Regulating the p38/JNK Pathway to Promote an Inflammatory Response in Renal Cell Carcinoma Cells.	0
34972816	2022	Human gut-microbiome-derived propionate coordinates proteasomal degradation via HECTD2 upregulation to target EHMT2 in colorectal cancer.	34
34972816	2022	Human gut-microbiome-derived propionate coordinates proteasomal degradation via HECTD2 upregulation to target EHMT2 in colorectal cancer.	34
23770851	2014	MiR-221 promotes the development of androgen independence in prostate cancer cells via downregulation of HECTD2 and RAB1A.	65
23770851	2014	MiR-221 promotes the development of androgen independence in prostate cancer cells via downregulation of HECTD2 and RAB1A.	65
21335971	2011	Absence of association between two HECTD2 polymorphisms and sporadic Creutzfeldt-Jakob disease.	3
21335971	2011	Absence of association between two HECTD2 polymorphisms and sporadic Creutzfeldt-Jakob disease.	3
19214206	2009	HECTD2 is associated with susceptibility to mouse and human prion disease.	38
19754925	2009	HECTD2, a candidate susceptibility gene for Alzheimer's disease on 10q.	8
19214206	2009	HECTD2 is associated with susceptibility to mouse and human prion disease.	38
19754925	2009	HECTD2, a candidate susceptibility gene for Alzheimer's disease on 10q.	8
16385451	2006	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	83
16385451	2006	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	83

Citation

Dessen P

HECTD2 (HECT domain E3 ubiquitin protein ligase 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46697/js/lib/js/lib/favicon/favicon-32x32.png