HECTD2 (HECT domain E3 ubiquitin protein ligase 2)

2007-04-01  

Identity

HGNC
LOCATION
10q23.32
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 143279
HGNC: 26736
Ensembl: ENSG00000165338

Variants:

dbSNP: 143279
ClinVar: 143279
TCGA: ENSG00000165338
COSMIC: HECTD2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165338ENST00000298068Q5U5R9
ENSG00000165338ENST00000371667X6R824
ENSG00000165338ENST00000371681Q5U5R9
ENSG00000165338ENST00000446394E7ERR3
ENSG00000165338ENST00000631422A0A0J9YVV1

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
386885912024HECTD2/TNFAIP1 Axis Regulating the p38/JNK Pathway to Promote an Inflammatory Response in Renal Cell Carcinoma Cells.0
386885912024HECTD2/TNFAIP1 Axis Regulating the p38/JNK Pathway to Promote an Inflammatory Response in Renal Cell Carcinoma Cells.0
349728162022Human gut-microbiome-derived propionate coordinates proteasomal degradation via HECTD2 upregulation to target EHMT2 in colorectal cancer.34
349728162022Human gut-microbiome-derived propionate coordinates proteasomal degradation via HECTD2 upregulation to target EHMT2 in colorectal cancer.34
237708512014MiR-221 promotes the development of androgen independence in prostate cancer cells via downregulation of HECTD2 and RAB1A.65
237708512014MiR-221 promotes the development of androgen independence in prostate cancer cells via downregulation of HECTD2 and RAB1A.65
213359712011Absence of association between two HECTD2 polymorphisms and sporadic Creutzfeldt-Jakob disease.3
213359712011Absence of association between two HECTD2 polymorphisms and sporadic Creutzfeldt-Jakob disease.3
192142062009HECTD2 is associated with susceptibility to mouse and human prion disease.38
197549252009HECTD2, a candidate susceptibility gene for Alzheimer's disease on 10q.8
192142062009HECTD2 is associated with susceptibility to mouse and human prion disease.38
197549252009HECTD2, a candidate susceptibility gene for Alzheimer's disease on 10q.8
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.83
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.83

Citation

Dessen P

HECTD2 (HECT domain E3 ubiquitin protein ligase 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46697/js/lib/teaching-explorer/favicon/favicon-16x16.png