NR2C2 (nuclear receptor subfamily 2 group C member 2)

2007-04-01  

Identity

HGNC
LOCATION
3p25.1
LOCUSID
ALIAS
TAK1,TR4
FUSION GENES

Other Information

Locus ID:

NCBI: 7182
MIM: 601426
HGNC: 7972
Ensembl: ENSG00000177463

Variants:

dbSNP: 7182
ClinVar: 7182
TCGA: ENSG00000177463
COSMIC: NR2C2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177463ENST00000323373P49116
ENSG00000177463ENST00000323373F2YGU2
ENSG00000177463ENST00000393102P49116
ENSG00000177463ENST00000406272P49116
ENSG00000177463ENST00000413118C9JMI6
ENSG00000177463ENST00000413194H7C3R1
ENSG00000177463ENST00000425241P49116
ENSG00000177463ENST00000435454C9J2Y1
ENSG00000177463ENST00000437120C9JKS0
ENSG00000177463ENST00000439011H7C3L1
ENSG00000177463ENST00000617312P49116
ENSG00000177463ENST00000617312F2YGU2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Nuclear Receptor transcription pathwayREACTOMER-HSA-383280

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
226412182013TGF-β and NF-κB signal pathway cross-talk is mediated through TAK1 and SMAD7 in a subset of head and neck cancers.77
225449252012Mycobacterium tuberculosis modulates macrophage lipid-sensing nuclear receptors PPARγ and TR4 for survival.73
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
120937442002An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer.55
245651012014MicroRNA-26b suppresses the NF-κB signaling and enhances the chemosensitivity of hepatocellular carcinoma cells by targeting TAK1 and TAB3.55
213310782011USP4 targets TAK1 to downregulate TNFα-induced NF-κB activation.51
275303522017The long non-coding RNA, SNHG6-003, functions as a competing endogenous RNA to promote the progression of hepatocellular carcinoma.51
210683812011The orphan nuclear receptor TR4 is a vitamin A-activated nuclear receptor.34
249425712014Enterovirus 71 3C inhibits cytokine expression through cleavage of the TAK1/TAB1/TAB2/TAB3 complex.34
176013502007A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.27

Citation

Dessen P

NR2C2 (nuclear receptor subfamily 2 group C member 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46702/nr2c2-(nuclear-receptor-subfamily-2-group-c-member-2)