QKI (QKI, KH domain containing RNA binding)

2007-04-01  

Identity

HGNC
QKI
LOCATION
6q26
LOCUSID
9444
ALIAS
Hqk,QK,QK1,QK3,hqkI
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9444
MIM: 609590
HGNC: 21100
Ensembl: ENSG00000112531

Variants:

dbSNP: 9444
ClinVar: 9444
TCGA: ENSG00000112531
COSMIC: QKI

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112531ENST00000275262Q96PU8
ENSG00000112531ENST00000361195Q96PU8
ENSG00000112531ENST00000361752Q96PU8
ENSG00000112531ENST00000361758Q96PU8
ENSG00000112531ENST00000392127Q96PU8
ENSG00000112531ENST00000424802Q96PU8
ENSG00000112531ENST00000453779Q96PU8
ENSG00000112531ENST00000537041F5GXS8
ENSG00000112531ENST00000537124F5H5U6
ENSG00000112531ENST00000537883H0YG47
ENSG00000112531ENST00000544361H0YGD6
ENSG00000112531ENST00000544436F5H8C8
ENSG00000112531ENST00000544823F5GYM3
ENSG00000112531ENST00000545346F5GYT7
ENSG00000112531ENST00000545607H0YFB7

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Oncogenic MAPK signalingREACTOMER-HSA-6802957
Signaling by BRAF and RAF fusionsREACTOMER-HSA-6802952

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
257689082015The RNA binding protein quaking regulates formation of circRNAs.441
247222552014The RNA-binding protein QKI suppresses cancer-associated aberrant splicing.72
166410982006Human QKI, a potential regulator of mRNA expression of human oligodendrocyte-related genes involved in schizophrenia.71
218442272011QKI-mediated alternative splicing of the histone variant MacroH2A1 regulates cancer cell proliferation.65
177870182008New implications for the QUAKING RNA binding protein in human disease.60
235258002013Quaking and PTB control overlapping splicing regulatory networks during muscle cell differentiation.58
196867452010RNA-binding protein quaking, a critical regulator of colon epithelial differentiation and a suppressor of colon cancer.54
224905192013miR-574-5p negatively regulates Qki6/7 to impact β-catenin/Wnt signalling and the development of colorectal cancer.51
268297512016MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism.51
227515002012STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA.49

Citation

Dessen P

QKI (QKI, KH domain containing RNA binding)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46703/qki