HDAC7 (histone deacetylase 7)

2007-04-01  

Identity

HGNC
LOCATION
12q13.11
LOCUSID
ALIAS
HD7,HD7A,HDAC7A
FUSION GENES

Other Information

Locus ID:

NCBI: 51564
MIM: 606542
HGNC: 14067
Ensembl: ENSG00000061273

Variants:

dbSNP: 51564
ClinVar: 51564
TCGA: ENSG00000061273
COSMIC: HDAC7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000061273ENST00000080059Q8WUI4
ENSG00000061273ENST00000354334Q8WUI4
ENSG00000061273ENST00000380610J3KPH8
ENSG00000061273ENST00000417107C9JZ79
ENSG00000061273ENST00000417902C9JVZ1
ENSG00000061273ENST00000421231C9J102
ENSG00000061273ENST00000422254C9JF80
ENSG00000061273ENST00000425451C9JKN3
ENSG00000061273ENST00000427332Q8WUI4
ENSG00000061273ENST00000430670C9JEB6
ENSG00000061273ENST00000433685C9JGF5
ENSG00000061273ENST00000434070C9JNI4
ENSG00000061273ENST00000440293C9JAH2
ENSG00000061273ENST00000445237C9JH46
ENSG00000061273ENST00000447463C9JNI4
ENSG00000061273ENST00000450805C9JBC2
ENSG00000061273ENST00000477203F8VWY3
ENSG00000061273ENST00000485796H0YI41
ENSG00000061273ENST00000488927A0A087WYQ4
ENSG00000061273ENST00000547259H0YHJ5
ENSG00000061273ENST00000548080H0YH91
ENSG00000061273ENST00000548938H0YI15
ENSG00000061273ENST00000552960Q8WUI4

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
SUMOylation of DNA damage response and repair proteinsREACTOMER-HSA-3108214
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Signaling by NOTCH1 in CancerREACTOMER-HSA-2644603
Signaling by NOTCH1 PEST Domain Mutants in CancerREACTOMER-HSA-2644602
Constitutive Signaling by NOTCH1 PEST Domain MutantsREACTOMER-HSA-2644606
Signaling by NOTCH1 HD+PEST Domain Mutants in CancerREACTOMER-HSA-2894858
Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsREACTOMER-HSA-2894862
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Signaling by NOTCH1REACTOMER-HSA-1980143
NOTCH1 Intracellular Domain Regulates TranscriptionREACTOMER-HSA-2122947

References

Pubmed IDYearTitleCitations
106402762000Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression.138
199667892010Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.118
182853382008Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity.88
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75
127537452003HDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis.74
185090612008Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7.73
152803642004Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity.71
157380542005Phosphorylation of histone deacetylase 7 by protein kinase D mediates T cell receptor-induced Nur77 expression and apoptosis.67
179977102008Histone deacetylase 7 associates with Runx2 and represses its activity during osteoblast maturation in a deacetylation-independent manner.60

Citation

Dessen P

HDAC7 (histone deacetylase 7)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46734/hdac7-(histone-deacetylase-7)