DDX4 (DEAD-box helicase 4)

2007-04-01  

Identity

HGNC
DDX4
LOCATION
5q11.2
LOCUSID
54514
ALIAS
VASA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54514
MIM: 605281
HGNC: 18700
Ensembl: ENSG00000152670

Variants:

dbSNP: 54514
ClinVar: 54514
TCGA: ENSG00000152670
COSMIC: DDX4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152670ENST00000353507Q9NQI0
ENSG00000152670ENST00000354991Q9NQI0
ENSG00000152670ENST00000503129H0Y960
ENSG00000152670ENST00000505374Q9NQI0
ENSG00000152670ENST00000506511D6RCM4
ENSG00000152670ENST00000506848D6RAF5
ENSG00000152670ENST00000507645H0YBW0
ENSG00000152670ENST00000511491D6RIB2
ENSG00000152670ENST00000511853Q9NQI0
ENSG00000152670ENST00000514278Q9NQI0
ENSG00000152670ENST00000514679D6RBL3
ENSG00000152670ENST00000515709D6RAT7

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Gene Silencing by RNAREACTOMER-HSA-211000
PIWI-interacting RNA (piRNA) biogenesisREACTOMER-HSA-5601884

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
363479252023Discriminating activities of DEAD-Box Helicase 41 from myeloid malignancy-associated germline variants by genetic rescue.0
366534742023The germline factor DDX4 contributes to the chemoresistance of small cell lung cancer cells.3
363479252023Discriminating activities of DEAD-Box Helicase 41 from myeloid malignancy-associated germline variants by genetic rescue.0
366534742023The germline factor DDX4 contributes to the chemoresistance of small cell lung cancer cells.3
362419082022VASA protein and gene expression analysis of human non-obstructive azoospermia and normal by immunohistochemistry, immunocytochemistry, and bioinformatics analysis.5
362419082022VASA protein and gene expression analysis of human non-obstructive azoospermia and normal by immunohistochemistry, immunocytochemistry, and bioinformatics analysis.5
328470442020DEAD-Box Helicase 4 (Ddx4)(+) Stem Cells Sustain Tumor Progression in Non-Serous Ovarian Cancers.2
328470442020DEAD-Box Helicase 4 (Ddx4)(+) Stem Cells Sustain Tumor Progression in Non-Serous Ovarian Cancers.2
312128432019Extracellular Localisation of the C-Terminus of DDX4 Confirmed by Immunocytochemistry and Fluorescence-Activated Cell Sorting.8
312128432019Extracellular Localisation of the C-Terminus of DDX4 Confirmed by Immunocytochemistry and Fluorescence-Activated Cell Sorting.8
297250362018Initial characterisation of adult human ovarian cell populations isolated by DDX4 expression and aldehyde dehydrogenase activity.35
297250362018Initial characterisation of adult human ovarian cell populations isolated by DDX4 expression and aldehyde dehydrogenase activity.35
280009272017Does detection of DDX4 mRNA in cell-free seminal plasma represents a reliable noninvasive germ cell marker in patients with nonobstructive azoospermia?2
283429262017Causes and Clinical Features of Infertile Men With Nonobstructive Azoospermia and Histopathologic Diagnosis of Hypospermatogenesis.6
286125122017Germline factor DDX4 functions in blood-derived cancer cell phenotypes.15

Citation

Dessen P

DDX4 (DEAD-box helicase 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46735/img/js/lib/js/lib/jquery-3.5.1.min.js