AKR1A1 (aldo-keto reductase family 1 member A1)

2007-04-01  

Identity

HGNC
LOCATION
1p34.1
LOCUSID
ALIAS
ALDR1,ALR,ARM,DD3,HEL-S-6
FUSION GENES

Other Information

Locus ID:

NCBI: 10327
MIM: 103830
HGNC: 380
Ensembl: ENSG00000117448

Variants:

dbSNP: 10327
ClinVar: 10327
TCGA: ENSG00000117448
COSMIC: AKR1A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000117448ENST00000351829P14550
ENSG00000117448ENST00000351829V9HWI0
ENSG00000117448ENST00000372070P14550
ENSG00000117448ENST00000372070V9HWI0
ENSG00000117448ENST00000434299Q5T621
ENSG00000117448ENST00000471651V9GYG2
ENSG00000117448ENST00000481885V9GYP9
ENSG00000117448ENST00000621846P14550
ENSG00000117448ENST00000621846V9HWI0

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Glycolysis / GluconeogenesisKEGGko00010
Pentose and glucuronate interconversionsKEGGko00040
Glycerolipid metabolismKEGGko00561
Glycolysis / GluconeogenesisKEGGhsa00010
Pentose and glucuronate interconversionsKEGGhsa00040
Glycerolipid metabolismKEGGhsa00561
Metabolic pathwaysKEGGhsa01100
Glucuronate pathway (uronate pathway)KEGGM00014
Glucuronate pathway (uronate pathway)KEGGhsa_M00014
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Glutathione conjugationREACTOMER-HSA-156590
Catabolism of glucuronate to xylulose-5-phosphateREACTOMER-HSA-5661270

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA449412doxorubicinChemicalPathwayassociated21048526

References

Pubmed IDYearTitleCitations
165432472006Polymorphisms in oxidative stress genes and risk for non-Hodgkin lymphoma.36
186766802008Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.32
171496002007Genetic polymorphisms in the oxidative stress pathway and susceptibility to non-Hodgkin lymphoma.26
196921682010Genetic susceptibility to distinct bladder cancer subphenotypes.25
204530002010A Large-scale genetic association study of esophageal adenocarcinoma risk.23
196251762009PTEN identified as important risk factor of chronic obstructive pulmonary disease.12
184951582008Merging the binding sites of aldose and aldehyde reductase for detection of inhibitor selectivity-determining features.5
191701962009Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.5
194235212009Genetic polymorphisms in nitric oxide synthase genes modify the relationship between vegetable and fruit intake and risk of non-Hodgkin lymphoma.4
157695972005The structure of Apo R268A human aldose reductase: hinges and latches that control the kinetic mechanism.2

Citation

Dessen P

AKR1A1 (aldo-keto reductase family 1 member A1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46740/akr1a1