AKAP4 (A-kinase anchoring protein 4)

2007-04-01  

Identity

HGNC
LOCATION
Xp11.22
LOCUSID
ALIAS
AKAP 82,AKAP-4,AKAP82,CT99,FSC1,HI,PRKA4,hAKAP82,p82
FUSION GENES

Other Information

Locus ID:

NCBI: 8852
MIM: 300185
HGNC: 374
Ensembl: ENSG00000147081

Variants:

dbSNP: 8852
ClinVar: 8852
TCGA: ENSG00000147081
COSMIC: AKAP4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147081ENST00000358526Q5JQC9
ENSG00000147081ENST00000358526A0A384MQY7
ENSG00000147081ENST00000376064Q5JQC9
ENSG00000147081ENST00000437370A0A075B6R4
ENSG00000147081ENST00000448865A0A075B6Q6

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
500

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
176830362007Human spermatozoa contain multiple targets for protein S-nitrosylation: an alternative mechanism of the modulation of sperm function by nitric oxide?43
215201582012Identification of AKAP-4 as a new cancer/testis antigen for detection and immunotherapy of prostate cancer.22
257391192015Novel antigens in non-small cell lung cancer: SP17, AKAP4, and PTTG1 are potential immunotherapeutic targets.17
234511562013A novel cancer testis antigen, A-kinase anchor protein 4 (AKAP4) is a potential biomarker for breast cancer.15
265908052015A-kinase anchor protein 4 (AKAP4) a promising therapeutic target of colorectal cancer.13
234782212013Expression and humoral response of A-kinase anchor protein 4 in cervical cancer.11
237649002013Gene silencing of A-kinase anchor protein 4 inhibits cervical cancer growth in vitro and in vivo.10
177124812007Localization of AKAP4 and tubulin proteins in sperm with reduced motility.9
261608342015AKAP4 is a circulating biomarker for non-small cell lung cancer.9
279010582016A-Kinase Anchoring Protein 4 (AKAP4) is an ERK1/2 substrate and a switch molecule between cAMP/PKA and PKC/ERK1/2 in human spermatozoa.5

Citation

Dessen P

AKAP4 (A-kinase anchoring protein 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46741/akap4-(a-kinase-anchoring-protein-4)