P4HTM (prolyl 4-hydroxylase, transmembrane)

2007-04-01  

Identity

HGNC
LOCATION
3p21.31
LOCUSID
ALIAS
EGLN4,HIDEA,HIFPH4,P4H-TM,PH-4,PH4,PHD4
FUSION GENES

Other Information

Locus ID:

NCBI: 54681
MIM: 614584
HGNC: 28858
Ensembl: ENSG00000178467

Variants:

dbSNP: 54681
ClinVar: 54681
TCGA: ENSG00000178467
COSMIC: P4HTM

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000178467ENST00000343546Q9NXG6
ENSG00000178467ENST00000383729Q9NXG6
ENSG00000178467ENST00000444213H7C153
ENSG00000178467ENST00000472796V9GYK5
ENSG00000178467ENST00000475629A0A0C4DGS7
ENSG00000178467ENST00000491739V9GY20

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
127889212003Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor.218
161545312005Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases.74
121630232002Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors.33
154567512004The peptide-substrate-binding domain of collagen prolyl 4-hydroxylases is a tetratricopeptide repeat domain with functional aromatic residues.13
248955552014The hypoxia-inducible factor pathway, prolyl hydroxylase domain protein inhibitors, and their roles in bone repair and regeneration.13
278403182016Sestrin2 inhibits hypoxia-inducible factor-1α accumulation via AMPK-mediated prolyl hydroxylase regulation.5
232412412012Human prolyl hydroxylase expression in uterine leiomyoma during the menstrual cycle.1

Citation

Dessen P

P4HTM (prolyl 4-hydroxylase, transmembrane)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46815/p4htm