ALDOA (aldolase, fructose-bisphosphate A)

2007-04-01 Affiliation

Identity

HGNC

ALDOA

LOCATION

16p11.2

LOCUSID

226

ALIAS

ALDA,GSD12,HEL-S-87p

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 226
MIM: 103850
HGNC: 414
Ensembl: ENSG00000149925

Variants:

dbSNP: 226
ClinVar: 226
TCGA: ENSG00000149925
COSMIC: ALDOA

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000149925	ENST00000395240	J3KPS3
ENSG00000149925	ENST00000412304	P04075
ENSG00000149925	ENST00000412304	V9HWN7
ENSG00000149925	ENST00000562168	H3BR04
ENSG00000149925	ENST00000562679	H3BPS8
ENSG00000149925	ENST00000563060	P04075
ENSG00000149925	ENST00000563060	V9HWN7
ENSG00000149925	ENST00000563987	H3BUH7
ENSG00000149925	ENST00000564688	H3BU78
ENSG00000149925	ENST00000565355	H3BR68
ENSG00000149925	ENST00000566846	H3BMQ8
ENSG00000149925	ENST00000569545	P04075
ENSG00000149925	ENST00000569545	V9HWN7
ENSG00000149925	ENST00000569798	H3BQN4
ENSG00000149925	ENST00000642816	P04075
ENSG00000149925	ENST00000643777	P04075
ENSG00000149925	ENST00000643777	V9HWN7

Expression (GTEx)

500

1000

1500

2000

2500

3000

3500

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Glycolysis / Gluconeogenesis	KEGG	ko00010
Pentose phosphate pathway	KEGG	ko00030
Fructose and mannose metabolism	KEGG	ko00051
Glycolysis / Gluconeogenesis	KEGG	hsa00010
Pentose phosphate pathway	KEGG	hsa00030
Fructose and mannose metabolism	KEGG	hsa00051
Metabolic pathways	KEGG	hsa01100
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate	KEGG	hsa_M00001
Gluconeogenesis, oxaloacetate => fructose-6P	KEGG	hsa_M00003
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate	KEGG	M00001
Gluconeogenesis, oxaloacetate => fructose-6P	KEGG	M00003
HIF-1 signaling pathway	KEGG	hsa04066
Biosynthesis of amino acids	KEGG	hsa01230
Biosynthesis of amino acids	KEGG	ko01230
Carbon metabolism	KEGG	hsa01200
Carbon metabolism	KEGG	ko01200
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
Response to elevated platelet cytosolic Ca2+	REACTOME	R-HSA-76005
Platelet degranulation	REACTOME	R-HSA-114608
Metabolism	REACTOME	R-HSA-1430728
Metabolism of carbohydrates	REACTOME	R-HSA-71387
Glucose metabolism	REACTOME	R-HSA-70326
Glycolysis	REACTOME	R-HSA-70171
Gluconeogenesis	REACTOME	R-HSA-70263
Neutrophil degranulation	REACTOME	R-HSA-6798695

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
26824656	2016	Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton.	74
21555518	2011	The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.	60
24465716	2014	Fructose-bisphosphate aldolase a is a potential metastasis-associated marker of lung squamous cell carcinoma and promotes lung cell tumorigenesis and migration.	36
19242545	2009	Association and mutation analyses of 16p11.2 autism candidate genes.	35
20381070	2010	Sex-specific proteome differences in the anterior cingulate cortex of schizophrenia.	22
20181627	2010	Identification of melanoma antigens using a Serological Proteome Approach (SERPA).	21
26854714	2016	ALDOA functions as an oncogene in the highly metastatic pancreatic cancer.	21
22996014	2012	New prognosis biomarkers identified by dynamic proteomic analysis of colorectal cancer.	19
21307348	2011	Aldolase directly interacts with ARNO and modulates cell morphology and acidic vesicle distribution.	18
24993527	2014	Aldolase positively regulates of the canonical Wnt signaling pathway.	17

Citation

Dessen P

ALDOA (aldolase, fructose-bisphosphate A)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46848/aldoa