UBE2L6 (ubiquitin conjugating enzyme E2 L6)

2007-04-01  

Identity

HGNC
UBE2L6
LOCATION
11q12.1
LOCUSID
9246
ALIAS
RIG-B,UBCH8
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9246
MIM: 603890
HGNC: 12490
Ensembl: ENSG00000156587

Variants:

dbSNP: 9246
ClinVar: 9246
TCGA: ENSG00000156587
COSMIC: UBE2L6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156587ENST00000287156O14933
ENSG00000156587ENST00000340573O14933
ENSG00000156587ENST00000526659E9PQT7
ENSG00000156587ENST00000527022E9PKW8

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Parkinson's diseaseKEGGhsa05012
Metabolism of proteinsREACTOMER-HSA-392499
Amyloid fiber formationREACTOMER-HSA-977225
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Innate Immune SystemREACTOMER-HSA-168249
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
Negative regulators of RIG-I/MDA5 signalingREACTOMER-HSA-936440
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Antiviral mechanism by IFN-stimulated genesREACTOMER-HSA-1169410
ISG15 antiviral mechanismREACTOMER-HSA-1169408
DNA RepairREACTOMER-HSA-73894
DNA Damage BypassREACTOMER-HSA-73893
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templateREACTOMER-HSA-110313
Termination of translesion DNA synthesisREACTOMER-HSA-5656169

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
375001762023Association of UBE2L6 and ABCB6 Expression With Platinum Resistance in Serous Ovarian Carcinoma.0
375001762023Association of UBE2L6 and ABCB6 Expression With Platinum Resistance in Serous Ovarian Carcinoma.0
347733652021Increased UBE2L6 regulated by type 1 interferon as potential marker in TB.8
347733652021Increased UBE2L6 regulated by type 1 interferon as potential marker in TB.8
318208452020Inhibition of UBE2L6 attenuates ISGylation and impedes ATRA-induced differentiation of leukemic cells.6
323296962020UBE2L6 is Involved in Cisplatin Resistance by Regulating the Transcription of ABCB6.11
332422552020An integrative analysis identifying transcriptional features and key genes involved in COVID-19.8
318208452020Inhibition of UBE2L6 attenuates ISGylation and impedes ATRA-induced differentiation of leukemic cells.6
323296962020UBE2L6 is Involved in Cisplatin Resistance by Regulating the Transcription of ABCB6.11
332422552020An integrative analysis identifying transcriptional features and key genes involved in COVID-19.8
314289032019Up-regulation of interferon-stimulated gene 15 and its conjugation machinery, UbE1L and UbcH8 expression by tumor necrosis factor-α through p38 MAPK and JNK signaling pathways in human lung carcinoma.9
314289032019Up-regulation of interferon-stimulated gene 15 and its conjugation machinery, UbE1L and UbcH8 expression by tumor necrosis factor-α through p38 MAPK and JNK signaling pathways in human lung carcinoma.9
291570762018UHRF1 epigenetically down-regulates UbcH8 to inhibit apoptosis in cervical cancer cells.17
291570762018UHRF1 epigenetically down-regulates UbcH8 to inhibit apoptosis in cervical cancer cells.17
281869902017UBE2L6/UBCH8 and ISG15 attenuate autophagy in esophageal cancer cells.24

Citation

Dessen P

UBE2L6 (ubiquitin conjugating enzyme E2 L6)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46868/tumors-explorer/img/logo-atlas-4.svg