DNAJA2 (DnaJ heat shock protein family (Hsp40) member A2)

2007-04-01  

Identity

HGNC
LOCATION
16q11.2
LOCUSID
ALIAS
CPR3,DJ3,DJA2,DNAJ,DNJ3,HIRIP4,PRO3015,RDJ2
FUSION GENES

Other Information

Locus ID:

NCBI: 10294
MIM: 611322
HGNC: 14884
Ensembl: ENSG00000069345

Variants:

dbSNP: 10294
ClinVar: 10294
TCGA: ENSG00000069345
COSMIC: DNAJA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000069345ENST00000317089O60884
ENSG00000069345ENST00000317089A0A024R6S1
ENSG00000069345ENST00000563158I3L320
ENSG00000069345ENST00000617000A0A087WT48

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
243188772014Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro.50
199401152010Hsp40 chaperones promote degradation of the HERG potassium channel.42
186847112008Functional divergence between co-chaperones of Hsc70.38
230910612012The DNAJA2 substrate release mechanism is essential for chaperone-mediated folding.17
185950092009RDJ2 (DNAJA2) chaperones neural G protein signaling pathways.13
313958862019Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor.8
314085072019Hsp70 and DNAJA2 limit CFTR levels through degradation.2

Citation

Dessen P

DNAJA2 (DnaJ heat shock protein family (Hsp40) member A2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46879/dnaja2-(dnaj-heat-shock-protein-family-(hsp40)-member-a2)