FOXK2 (forkhead box K2)

2007-04-01  

Identity

HGNC
LOCATION
17q25.3
LOCUSID
ALIAS
ILF,ILF-1,ILF1,nGTBP
FUSION GENES

Other Information

Locus ID:

NCBI: 3607
MIM: 147685
HGNC: 6036
Ensembl: ENSG00000141568

Variants:

dbSNP: 3607
ClinVar: 3607
TCGA: ENSG00000141568
COSMIC: FOXK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141568ENST00000335255Q01167
ENSG00000141568ENST00000473637Q01167
ENSG00000141568ENST00000526383E9PPI7
ENSG00000141568ENST00000531030E9PM37
ENSG00000141568ENST00000575578I3L4U8

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
UCH proteinasesREACTOMER-HSA-5689603

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
258051362015FOXKs promote Wnt/β-catenin signaling by translocating DVL into the nucleus.40
208106542010Cell cycle-dependent regulation of the forkhead transcription factor FOXK2 by CDK·cyclin complexes.25
220839522012The forkhead transcription factor FOXK2 promotes AP-1-mediated transcriptional regulation.21
257407062015FOXK2 transcription factor suppresses ERα-positive breast cancer cell growth through down-regulating the stability of ERα via mechanism involving BRCA1/BARD1.16
254519222015BRCA1-associated protein 1 (BAP1) deubiquitinase antagonizes the ubiquitin-mediated activation of FoxK2 target genes.14
265785692016Genome-wide binding studies reveal DNA binding specificity mechanisms and functional interplay amongst Forkhead transcription factors.12
280076002017Sox9 mediated transcriptional activation of FOXK2 is critical for colorectal cancer cells proliferation.12
282600882017Foxk2 inhibits non-small cell lung cancer epithelial-mesenchymal transition and proliferation through the repression of different key target genes.9
285068572017FOXK2, regulted by miR-1271-5p, promotes cell growth and indicates unfavorable prognosis in hepatocellular carcinoma.9
307009092019FOXK1 and FOXK2 regulate aerobic glycolysis.8

Citation

Dessen P

FOXK2 (forkhead box K2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46881/foxk2