FOXK2 (forkhead box K2)

2007-04-01  

Identity

HGNC
FOXK2
LOCATION
17q25.3
LOCUSID
3607
ALIAS
ILF,ILF-1,ILF1,nGTBP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3607
MIM: 147685
HGNC: 6036
Ensembl: ENSG00000141568

Variants:

dbSNP: 3607
ClinVar: 3607
TCGA: ENSG00000141568
COSMIC: FOXK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141568ENST00000335255Q01167
ENSG00000141568ENST00000473637Q01167
ENSG00000141568ENST00000526383E9PPI7
ENSG00000141568ENST00000531030E9PM37
ENSG00000141568ENST00000575578I3L4U8

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
UCH proteinasesREACTOMER-HSA-5689603

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
387354742024FOXK2 targeting by the SCF-E3 ligase subunit FBXO24 for ubiquitin mediated degradation modulates mitochondrial respiration.0
387354742024FOXK2 targeting by the SCF-E3 ligase subunit FBXO24 for ubiquitin mediated degradation modulates mitochondrial respiration.0
366822222023FOXK2 affects cancer cell response to chemotherapy by promoting nucleotide de novo synthesis.6
369228722023CircFOXK2 promotes hepatocellular carcinoma progression and leads to a poor clinical prognosis via regulating the Warburg effect.4
373562822023FOXK2 regulates PFKFB3 in promoting glycolysis and tumorigenesis in multiple myeloma.0
366822222023FOXK2 affects cancer cell response to chemotherapy by promoting nucleotide de novo synthesis.6
369228722023CircFOXK2 promotes hepatocellular carcinoma progression and leads to a poor clinical prognosis via regulating the Warburg effect.4
373562822023FOXK2 regulates PFKFB3 in promoting glycolysis and tumorigenesis in multiple myeloma.0
350903772022Long non-coding RNA tumor protein 53 target gene 1 promotes cervical cancer development via regulating microRNA-33a-5p to target forkhead box K2.7
353494892022FOXK2 promotes ovarian cancer stemness by regulating the unfolded protein response pathway.16
350903772022Long non-coding RNA tumor protein 53 target gene 1 promotes cervical cancer development via regulating microRNA-33a-5p to target forkhead box K2.7
353494892022FOXK2 promotes ovarian cancer stemness by regulating the unfolded protein response pathway.16
326835822021Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network.13
334342642021The forkhead transcription factor FOXK2 premarks lineage-specific genes in human embryonic stem cells for activation during differentiation.7
343291932021CircRNA circFOXK2 facilitates oncogenesis in breast cancer via IGF2BP3/miR-370 axis.20

Citation

Dessen P

FOXK2 (forkhead box K2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46881/gene-fusions-explorer/gene-fusions/css/lib/dataTables.bootstrap.min.css