ADHFE1 (alcohol dehydrogenase iron containing 1)

2007-04-01  

Identity

HGNC
LOCATION
8q13.1
LOCUSID
ALIAS
ADH8,HMFT2263,HOT

Other Information

Locus ID:

NCBI: 137872
MIM: 611083
HGNC: 16354
Ensembl: ENSG00000147576

Variants:

dbSNP: 137872
ClinVar: 137872
TCGA: ENSG00000147576
COSMIC: ADHFE1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147576ENST00000276576F2Z3E5
ENSG00000147576ENST00000396621B4DV11
ENSG00000147576ENST00000396623Q8IWW8
ENSG00000147576ENST00000415254Q8IWW8
ENSG00000147576ENST00000419955F2Z3D8
ENSG00000147576ENST00000422166B4DFI7
ENSG00000147576ENST00000424777Q8IWW8
ENSG00000147576ENST00000426810F2Z3E5
ENSG00000147576ENST00000431959F2Z3D8
ENSG00000147576ENST00000443372F2Z2N0
ENSG00000147576ENST00000449512F2Z2N0

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Pyruvate metabolism and Citric Acid (TCA) cycleREACTOMER-HSA-71406
Interconversion of 2-oxoglutarate and 2-hydroxyglutarateREACTOMER-HSA-880009

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
190134392009Enzymes involved in the metabolism of gamma-hydroxybutyrate in SH-SY5Y cells: identification of an iron-dependent alcohol dehydrogenase ADHFe1.14
292024742018ADHFE1 is a breast cancer oncogene and induces metabolic reprogramming.14
248865992014Alcohol induces cell proliferation via hypermethylation of ADHFE1 in colorectal cancer cells.13
125927112002Cloning and characterization of a novel human alcohol dehydrogenase gene (ADHFe1).12
235171432013Alcohol dehydrogenase, iron containing, 1 promoter hypermethylation associated with colorectal cancer differentiation.9

Citation

Dessen P

ADHFE1 (alcohol dehydrogenase iron containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46902/adhfe1