ADHFE1 (alcohol dehydrogenase iron containing 1)

2007-04-01  

Identity

HGNC
ADHFE1
LOCATION
8q13.1
LOCUSID
137872
ALIAS
ADH8,HMFT2263,HOT

Other Information

Locus ID:

NCBI: 137872
MIM: 611083
HGNC: 16354
Ensembl: ENSG00000147576

Variants:

dbSNP: 137872
ClinVar: 137872
TCGA: ENSG00000147576
COSMIC: ADHFE1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147576ENST00000276576F2Z3E5
ENSG00000147576ENST00000396621B4DV11
ENSG00000147576ENST00000396623Q8IWW8
ENSG00000147576ENST00000415254Q8IWW8
ENSG00000147576ENST00000419955F2Z3D8
ENSG00000147576ENST00000422166B4DFI7
ENSG00000147576ENST00000424777Q8IWW8
ENSG00000147576ENST00000426810F2Z3E5
ENSG00000147576ENST00000431959F2Z3D8
ENSG00000147576ENST00000443372F2Z2N0
ENSG00000147576ENST00000449512F2Z2N0

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Pyruvate metabolism and Citric Acid (TCA) cycleREACTOMER-HSA-71406
Interconversion of 2-oxoglutarate and 2-hydroxyglutarateREACTOMER-HSA-880009

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
372704602023Combined detection of SDC2/ADHFE1/PPP2R5C methylation in stool DNA for colorectal cancer screening.1
372704602023Combined detection of SDC2/ADHFE1/PPP2R5C methylation in stool DNA for colorectal cancer screening.1
323170102020Genome-wide DNA methylation profiles of low- and high-grade adenoma reveals potential biomarkers for early detection of colorectal carcinoma.0
323170102020Genome-wide DNA methylation profiles of low- and high-grade adenoma reveals potential biomarkers for early detection of colorectal carcinoma.0
292024742018ADHFE1 is a breast cancer oncogene and induces metabolic reprogramming.39
292024742018ADHFE1 is a breast cancer oncogene and induces metabolic reprogramming.39
248865992014Alcohol induces cell proliferation via hypermethylation of ADHFE1 in colorectal cancer cells.19
248865992014Alcohol induces cell proliferation via hypermethylation of ADHFE1 in colorectal cancer cells.19
235171432013Alcohol dehydrogenase, iron containing, 1 promoter hypermethylation associated with colorectal cancer differentiation.12
235171432013Alcohol dehydrogenase, iron containing, 1 promoter hypermethylation associated with colorectal cancer differentiation.12
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
190134392009Enzymes involved in the metabolism of gamma-hydroxybutyrate in SH-SY5Y cells: identification of an iron-dependent alcohol dehydrogenase ADHFe1.16
190134392009Enzymes involved in the metabolism of gamma-hydroxybutyrate in SH-SY5Y cells: identification of an iron-dependent alcohol dehydrogenase ADHFe1.16
125927112002Cloning and characterization of a novel human alcohol dehydrogenase gene (ADHFe1).14

Citation

Dessen P

ADHFE1 (alcohol dehydrogenase iron containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46902/case-report-explorer/img/css/lib/bootstrap.min.css