DDX21 (DExD-box helicase 21)

2007-04-01  

Identity

HGNC
DDX21
LOCATION
10q22.1
LOCUSID
9188
ALIAS
GUA,GURDB,RH-II/GU,RH-II/GuA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9188
MIM: 606357
HGNC: 2744
Ensembl: ENSG00000165732

Variants:

dbSNP: 9188
ClinVar: 9188
TCGA: ENSG00000165732
COSMIC: DDX21

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165732ENST00000354185Q9NR30
ENSG00000165732ENST00000620315Q9NR30

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Epigenetic regulation of gene expressionREACTOMER-HSA-212165
Positive epigenetic regulation of rRNA expressionREACTOMER-HSA-5250913
B-WICH complex positively regulates rRNA expressionREACTOMER-HSA-5250924

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383877562024Lnc-PLCB1 is stabilized by METTL14 induced m6A modification and inhibits Helicobacter pylori mediated gastric cancer by destabilizing DDX21.1
385725892024m(6)A-dependent upregulation of DDX21 by super-enhancer-driven IGF2BP2 and IGF2BP3 facilitates progression of acute myeloid leukaemia.1
383877562024Lnc-PLCB1 is stabilized by METTL14 induced m6A modification and inhibits Helicobacter pylori mediated gastric cancer by destabilizing DDX21.1
385725892024m(6)A-dependent upregulation of DDX21 by super-enhancer-driven IGF2BP2 and IGF2BP3 facilitates progression of acute myeloid leukaemia.1
366086612023Glucose dissociates DDX21 dimers to regulate mRNA splicing and tissue differentiation.6
370293002023Phase separation of DDX21 promotes colorectal cancer metastasis via MCM5-dependent EMT pathway.10
370728112023LINC00240 in the 6p22.1 risk locus promotes gastric cancer progression through USP10-mediated DDX21 stabilization.4
379044562023RRP9 and DDX21 as new biomarkers of colorectal cancer.0
379882222023Joint effect of RRP9 and DDX21 on development of colorectal cancer and keloid.0
366086612023Glucose dissociates DDX21 dimers to regulate mRNA splicing and tissue differentiation.6
370293002023Phase separation of DDX21 promotes colorectal cancer metastasis via MCM5-dependent EMT pathway.10
370728112023LINC00240 in the 6p22.1 risk locus promotes gastric cancer progression through USP10-mediated DDX21 stabilization.4
379044562023RRP9 and DDX21 as new biomarkers of colorectal cancer.0
379882222023Joint effect of RRP9 and DDX21 on development of colorectal cancer and keloid.0
349870582022The Roles of RNA Helicases in DNA Damage Repair and Tumorigenesis Reveal Precision Therapeutic Strategies.9

Citation

Dessen P

DDX21 (DExD-box helicase 21)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46952/gene-explorer/img/logo-atlas-4.svg