INO80 (INO80 complex ATPase subunit)

2007-04-01  

Identity

HGNC
INO80
LOCATION
15q15.1
LOCUSID
54617
ALIAS
INO80A,INOC1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54617
MIM: 610169
HGNC: 26956
Ensembl: ENSG00000128908

Variants:

dbSNP: 54617
ClinVar: 54617
TCGA: ENSG00000128908
COSMIC: INO80

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128908ENST00000401393Q9ULG1
ENSG00000128908ENST00000401393A0A024R9R7
ENSG00000128908ENST00000557849H0YKH3
ENSG00000128908ENST00000558357H0YMN5
ENSG00000128908ENST00000559995H0YNL3
ENSG00000128908ENST00000616814A0A087X0U7
ENSG00000128908ENST00000648947Q9ULG1
ENSG00000128908ENST00000648947A0A024R9R7

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DNA RepairREACTOMER-HSA-73894
Nucleotide Excision RepairREACTOMER-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)REACTOMER-HSA-5696399
DNA Damage Recognition in GG-NERREACTOMER-HSA-5696394
DeubiquitinationREACTOMER-HSA-5688426
UCH proteinasesREACTOMER-HSA-5689603

References

Pubmed IDYearTitleCitations
336584352021CHIP and BAP1 Act in Concert to Regulate INO80 Ubiquitination and Stability for DNA Replication.6
337246482021INO80 participates in the pathogenesis of recurrent miscarriage by epigenetically regulating trophoblast migration and invasion.2
336584352021CHIP and BAP1 Act in Concert to Regulate INO80 Ubiquitination and Stability for DNA Replication.6
337246482021INO80 participates in the pathogenesis of recurrent miscarriage by epigenetically regulating trophoblast migration and invasion.2
329133302020Resolution of R-loops by INO80 promotes DNA replication and maintains cancer cell proliferation and viability.45
329604812020Linc-MYH configures INO80 to regulate muscle stem cell numbers and skeletal muscle hypertrophy.19
329133302020Resolution of R-loops by INO80 promotes DNA replication and maintains cancer cell proliferation and viability.45
329604812020Linc-MYH configures INO80 to regulate muscle stem cell numbers and skeletal muscle hypertrophy.19
306066112019Mammalian INO80 chromatin remodeler cooperates with FANCM to mediate DNA interstrand crosslink-induced checkpoint activation and repair.2
306066112019Mammalian INO80 chromatin remodeler cooperates with FANCM to mediate DNA interstrand crosslink-induced checkpoint activation and repair.2
293232712018Cryo-EM structures of the human INO80 chromatin-remodeling complex.25
293310302018Single-molecule nucleosome remodeling by INO80 and effects of histone tails.6
294321292018Identification of Two Distinct Classes of the Human INO80 Complex Genome-Wide.12
295617072018LncRNA PTCSC3 affects drug resistance of anaplastic thyroid cancer through STAT3/INO80 pathway.37
296435062018Structure and regulation of the human INO80-nucleosome complex.82

Citation

Dessen P

INO80 (INO80 complex ATPase subunit)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46976/gene-fusions/tumors-explorer/css/card-gene.css