PITPNM1 (phosphatidylinositol transfer protein membrane associated 1)

2007-04-01  

Identity

HGNC
PITPNM1
LOCATION
11q13.2
LOCUSID
9600
ALIAS
DRES9,NIR2,PITPNM,RDGB,RDGB1,RDGBA,RDGBA1,Rd9
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9600
MIM: 608794
HGNC: 9003
Ensembl: ENSG00000110697

Variants:

dbSNP: 9600
ClinVar: 9600
TCGA: ENSG00000110697
COSMIC: PITPNM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110697ENST00000356404O00562
ENSG00000110697ENST00000356404A0A024R5I7
ENSG00000110697ENST00000436757O00562
ENSG00000110697ENST00000524901E9PNU6
ENSG00000110697ENST00000528559E9PMZ6
ENSG00000110697ENST00000532703E9PMS0
ENSG00000110697ENST00000533391E9PSD1
ENSG00000110697ENST00000534749O00562
ENSG00000110697ENST00000534749A0A024R5I7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Synthesis of PIREACTOMER-HSA-1483226

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
345724782021Attenuation of PITPNM1 Signaling Cascade Can Inhibit Breast Cancer Progression.1
345724782021Attenuation of PITPNM1 Signaling Cascade Can Inhibit Breast Cancer Progression.1
314847472019Nir2 Is an Effector of VAPs Necessary for Efficient Hepatitis C Virus Replication and Phosphatidylinositol 4-Phosphate Enrichment at the Viral Replication Organelle.16
314847472019Nir2 Is an Effector of VAPs Necessary for Efficient Hepatitis C Virus Replication and Phosphatidylinositol 4-Phosphate Enrichment at the Viral Replication Organelle.16
258873992015Phosphatidylinositol 4,5-Bisphosphate Homeostasis Regulated by Nir2 and Nir3 Proteins at Endoplasmic Reticulum-Plasma Membrane Junctions.67
258873992015Phosphatidylinositol 4,5-Bisphosphate Homeostasis Regulated by Nir2 and Nir3 Proteins at Endoplasmic Reticulum-Plasma Membrane Junctions.67
251796022014The lipid-transfer protein Nir2 enhances epithelial-mesenchymal transition and facilitates breast cancer metastasis.18
251796022014The lipid-transfer protein Nir2 enhances epithelial-mesenchymal transition and facilitates breast cancer metastasis.18
238970882013The phosphatidylinositol-transfer protein Nir2 binds phosphatidic acid and positively regulates phosphoinositide signalling.63
241836672013Feedback regulation of receptor-induced Ca2+ signaling mediated by E-Syt1 and Nir2 at endoplasmic reticulum-plasma membrane junctions.180
238970882013The phosphatidylinositol-transfer protein Nir2 binds phosphatidic acid and positively regulates phosphoinositide signalling.63
241836672013Feedback regulation of receptor-induced Ca2+ signaling mediated by E-Syt1 and Nir2 at endoplasmic reticulum-plasma membrane junctions.180
170905282007Substrate specificity of RdgB protein, a deoxyribonucleoside triphosphate pyrophosphohydrolase.29
170905282007Substrate specificity of RdgB protein, a deoxyribonucleoside triphosphate pyrophosphohydrolase.29
157230572005Maintenance of the diacylglycerol level in the Golgi apparatus by the Nir2 protein is critical for Golgi secretory function.82

Citation

Dessen P

PITPNM1 (phosphatidylinositol transfer protein membrane associated 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46996/gene-explorer/favicon/favicon-32x32.png