AKAP1 (A-kinase anchoring protein 1)

2007-04-01  

Identity

HGNC
LOCATION
17q22
LOCUSID
ALIAS
AKAP,AKAP121,AKAP149,AKAP84,D-AKAP1,PPP1R43,PRKA1,SAKAP84,TDRD17
FUSION GENES

Other Information

Locus ID:

NCBI: 8165
MIM: 602449
HGNC: 367
Ensembl: ENSG00000121057

Variants:

dbSNP: 8165
ClinVar: 8165
TCGA: ENSG00000121057
COSMIC: AKAP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121057ENST00000314126Q92667
ENSG00000121057ENST00000337714Q92667
ENSG00000121057ENST00000337714A0A140VK05
ENSG00000121057ENST00000481416Q92667
ENSG00000121057ENST00000539273Q92667
ENSG00000121057ENST00000539273A0A140VK05
ENSG00000121057ENST00000570423A0A0G2JLF7
ENSG00000121057ENST00000571629Q92667
ENSG00000121057ENST00000571629A0A140VK05
ENSG00000121057ENST00000572156I3L2A2
ENSG00000121057ENST00000572557Q92667
ENSG00000121057ENST00000572557A0A140VK05
ENSG00000121057ENST00000572560I3L0V5
ENSG00000121057ENST00000572814I3L0K6
ENSG00000121057ENST00000573085I3L3L9
ENSG00000121057ENST00000573326I3NI36
ENSG00000121057ENST00000574683I3L364
ENSG00000121057ENST00000575032I3L3V6
ENSG00000121057ENST00000575186A0A0G2JLF7
ENSG00000121057ENST00000575322I3L2N7
ENSG00000121057ENST00000576295I3L0W0
ENSG00000121057ENST00000576591I3L3K1
ENSG00000121057ENST00000621116Q92667
ENSG00000121057ENST00000621116A0A140VK05

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
264376022015Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates.95
178846352007Isoform-specific PKA dynamics revealed by dye-triggered aggregation and DAKAP1alpha-mediated localization in living cells.27
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
206770142010An approach based on a genome-wide association study reveals candidate loci for narcolepsy.16
126978392003AKAP149 is a novel PP1 specifier required to maintain nuclear envelope integrity in G1 phase.15
285697812017Mitochondrial AKAP1 supports mTOR pathway and tumor growth.13
190744622009Mutually exclusive binding of PP1 and RNA to AKAP149 affects the mitochondrial network.12
230455252012Src homology 2 domain-containing phosphatase 2 (Shp2) is a component of the A-kinase-anchoring protein (AKAP)-Lbc complex and is inhibited by protein kinase A (PKA) under pathological hypertrophic conditions in the heart.12
124148072002AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex.11
230773462012Short RNA molecules with high binding affinity to the KH motif of A-kinase anchoring protein 1 (AKAP1): implications for the regulation of steroidogenesis.11

Citation

Dessen P

AKAP1 (A-kinase anchoring protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47108/akap1