HMGB3 (high mobility group box 3)

HMGB3 (high mobility group box 3)

2007-04-01 Affiliation

Identity

HGNC

LOCATION

Xq28

LOCUSID

ALIAS

HMG-2a,HMG-4,HMG2A,HMG4

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3149
MIM: 300193
HGNC: 5004
Ensembl: ENSG00000029993

Variants:

dbSNP: 3149
ClinVar: 3149
TCGA: ENSG00000029993
COSMIC: HMGB3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000029993	ENST00000325307	O15347
ENSG00000029993	ENST00000419110	E7ES08
ENSG00000029993	ENST00000430118	E9PES6
ENSG00000029993	ENST00000448905	O15347
ENSG00000029993	ENST00000455596	E7EQU1

Expression (GTEx)

0

5

10

15

20

25

30

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
38761792	2024	Exosomal HMGB3 released by glioma cells confers the activation of NLRP3 inflammasome and pyroptosis in tumor-associated macrophages.	1
39062899	2024	Structure and Functions of HMGB3 Protein.	0
38761792	2024	Exosomal HMGB3 released by glioma cells confers the activation of NLRP3 inflammasome and pyroptosis in tumor-associated macrophages.	1
39062899	2024	Structure and Functions of HMGB3 Protein.	0
36541373	2023	SOX9 and HMGB3 co-operatively transactivate NANOG and promote prostate cancer progression.	5
36542208	2023	Circ-IGF1R Affects the Progression of Colorectal Cancer by Activating the miR-362-5p/HMGB3-Mediated Wnt/β-Catenin Signal Pathway.	3
37328851	2023	HMGB3 promotes the malignant phenotypes and stemness of epithelial ovarian cancer through the MAPK/ERK signaling pathway.	7
36541373	2023	SOX9 and HMGB3 co-operatively transactivate NANOG and promote prostate cancer progression.	5
36542208	2023	Circ-IGF1R Affects the Progression of Colorectal Cancer by Activating the miR-362-5p/HMGB3-Mediated Wnt/β-Catenin Signal Pathway.	3
37328851	2023	HMGB3 promotes the malignant phenotypes and stemness of epithelial ovarian cancer through the MAPK/ERK signaling pathway.	7
34973275	2022	miR-142-3p simultaneously targets HMGA1, HMGA2, HMGB1, and HMGB3 and inhibits tumorigenic properties and in-vivo metastatic potential of human cervical cancer cells.	9
35332131	2022	HMGB3 promotes PARP inhibitor resistance through interacting with PARP1 in ovarian cancer.	13
35705019	2022	Long Noncoding RNA Brain Cytoplasmic RNA 1 Induces Cisplatin-Resistance of Cervical Cancer Cells by Sponging MicroRNA-330-5p and Upregulating High-Mobility Group Box 3.	1
34973275	2022	miR-142-3p simultaneously targets HMGA1, HMGA2, HMGB1, and HMGB3 and inhibits tumorigenic properties and in-vivo metastatic potential of human cervical cancer cells.	9
35332131	2022	HMGB3 promotes PARP inhibitor resistance through interacting with PARP1 in ovarian cancer.	13

Citation

Dessen P

HMGB3 (high mobility group box 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47167/cancer-prone-explorer/css/js/web-card-gene.js