HMGB3 (high mobility group box 3)

2007-04-01  

Identity

HGNC
LOCATION
Xq28
LOCUSID
ALIAS
HMG-2a,HMG-4,HMG2A,HMG4
FUSION GENES

Other Information

Locus ID:

NCBI: 3149
MIM: 300193
HGNC: 5004
Ensembl: ENSG00000029993

Variants:

dbSNP: 3149
ClinVar: 3149
TCGA: ENSG00000029993
COSMIC: HMGB3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000029993ENST00000325307O15347
ENSG00000029993ENST00000419110E7ES08
ENSG00000029993ENST00000430118E9PES6
ENSG00000029993ENST00000448905O15347
ENSG00000029993ENST00000455596E7EQU1

Expression (GTEx)

0
5
10
15
20
25
30

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
387617922024Exosomal HMGB3 released by glioma cells confers the activation of NLRP3 inflammasome and pyroptosis in tumor-associated macrophages.1
390628992024Structure and Functions of HMGB3 Protein.0
387617922024Exosomal HMGB3 released by glioma cells confers the activation of NLRP3 inflammasome and pyroptosis in tumor-associated macrophages.1
390628992024Structure and Functions of HMGB3 Protein.0
365413732023SOX9 and HMGB3 co-operatively transactivate NANOG and promote prostate cancer progression.5
365422082023Circ-IGF1R Affects the Progression of Colorectal Cancer by Activating the miR-362-5p/HMGB3-Mediated Wnt/β-Catenin Signal Pathway.3
373288512023HMGB3 promotes the malignant phenotypes and stemness of epithelial ovarian cancer through the MAPK/ERK signaling pathway.7
365413732023SOX9 and HMGB3 co-operatively transactivate NANOG and promote prostate cancer progression.5
365422082023Circ-IGF1R Affects the Progression of Colorectal Cancer by Activating the miR-362-5p/HMGB3-Mediated Wnt/β-Catenin Signal Pathway.3
373288512023HMGB3 promotes the malignant phenotypes and stemness of epithelial ovarian cancer through the MAPK/ERK signaling pathway.7
349732752022miR-142-3p simultaneously targets HMGA1, HMGA2, HMGB1, and HMGB3 and inhibits tumorigenic properties and in-vivo metastatic potential of human cervical cancer cells.9
353321312022HMGB3 promotes PARP inhibitor resistance through interacting with PARP1 in ovarian cancer.13
357050192022Long Noncoding RNA Brain Cytoplasmic RNA 1 Induces Cisplatin-Resistance of Cervical Cancer Cells by Sponging MicroRNA-330-5p and Upregulating High-Mobility Group Box 3.1
349732752022miR-142-3p simultaneously targets HMGA1, HMGA2, HMGB1, and HMGB3 and inhibits tumorigenic properties and in-vivo metastatic potential of human cervical cancer cells.9
353321312022HMGB3 promotes PARP inhibitor resistance through interacting with PARP1 in ovarian cancer.13

Citation

Dessen P

HMGB3 (high mobility group box 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47167/cancer-prone-explorer/deep-insight-explorer/img/logo-atlas-4.svg